The 2021 Saitama Seibu Lions season was the 71st season of the franchise in Nippon Professional Baseball, their 42nd season in Saitama, under Seibu Group, and playing at the MetLife Dome. It was the team's 4th season under manager Hatsuhiko Tsuji, who has managed the Lions for 4 years. The Lions, for the 2nd year in a row, failed to qualify for the playoffs, going all the way down in last place.

Regular season The Lions finished in 6th place, going 55–70–18, with a .440 winning percentage. This is the 2nd year in a row the Lions failed to qualify for the playoffs. +2021 Pacific League standingsPosTeamGPWLT.PctGBHomeRoad1Orix Buffaloes143705518.560—38-22-1232–33–62Chiba Lotte Marines143675719.5402½33-32-734–25–123Tohoku Rakuten Golden Eagles143666215.5145½31-33-835–29–74Fukuoka SoftBank Hawks143606221.4928½31-29-1129–33–105Hokkaido Nippon-Ham Fighters143556820.4471425-36-1030–32–106Saitama Seibu Lions143557018.4401530-34-725–36–11

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