The 2005 Western Illinois Leathernecks football team represented Western Illinois University as a member of the Gateway Football Conference during the 2005 NCAA Division I-AA football season. They were led by seventh-year head coach Don Patterson and played their home games at Hanson Field in Macomb, Illinois. The Leathernecks finished the season with a 5–6 record overall and a 3–4 record in conference play.
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