The Girls Independent Schools League (GISL) is a high school athletic conference comprising private all-female Christian high schools located in the St. Louis, Missouri metro area.

Member schools School Nickname Colors City County School type Cor Jesu Chargers Affton St. Louis Private/All Female Incarnate Word Red Knights Bel-Nor St. Louis Private/All Female Nerinx Hall Markers Webster Groves St. Louis Private/All FemaleNotre DameRebels LemaySt. LouisPrivate/All FemaleSt. DominicCrusaders O'FallonSt. CharlesPrivate St. Joseph's Angels Frontenac St. Louis Private/All Female Ursuline Bears Glendale St. Louis Private/All Female Villa Duchesne Saints Frontenac St. Louis Private/All Female Visitation Academy Vivettes Town and Country St. Louis Private/All Female

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History

The GISL had its inaugural season in the 2023–2024 school year.

The Metro Women's Athletics Association (MWAA) was a high school athletic conference comprising private all-female Catholic high schools for over 30 years. Before the establishment of the GISL, Cor Jesu, Incarnate Word, Nerinx Hall, St Joseph's, Ursuline, Villa Duchesne, and Visitation Academy were members of the MWAA. Additionally, Barat Academy and Whitfield School participated in sports as independent schools, but competed against the schools of the MWAA in some sports.

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