The 2022 Santa Cruz Challenger, also known as Dove MEN + CARE Challenger Bolivia, was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Santa Cruz de la Sierra, Bolivia between 24 and 30 January 2022.

Singles main-draw entrants Seeds Country Player Rank1 SeedHugo Dellien1141Andrej Martin1162Francisco Cerúndolo1273Tomás Martín Etcheverry1314Zdeněk Kolář1435Fernando Verdasco1706Facundo Mena2097Camilo Ugo Carabelli2158 1 Rankings are as of 17 January 2022.

Other entrants The following players received wildcards into the singles main draw: Boris Arias Murkel Dellien Federico Zeballos

The following player received entry into the singles main draw as an alternate: Nicolás Álvarez

The following players received entry from the qualifying draw: Pedro Cachin Matías Franco Descotte Diego Hidalgo Juan Carlos Prado Ángelo Cristian Rodríguez Gonzalo Villanueva

The following player received entry as a lucky loser: Michel Vernier

Champions Singles

Francisco Cerúndolo def. Camilo Ugo Carabelli 6–4, 6–3.

Doubles

Diego Hidalgo / Cristian Rodríguez def. Andrej Martin / Tristan-Samuel Weissborn 4–6, 6–3, [10–8].

References