Polysubstance use or multisubstance use is the use of combinations of psychoactive substances with both legal and illegal substances. This page lists polysubstance combinations that are entheogenic, recreational, or off-label indicated use of pharmaceuticals. For example, the over-the-counter motion sickness combination drug dimenhydrinate (8-chlorotheophylline/diphenhydramine) is occasionally used in higher doses as a deliriant. The prescription medicine Adderall (dextroamphetamine sulfate/amphetamine sulfate/dextroamphetamine saccharate/amphetamine aspartate monohydrate) is also frequently used recreationally. However, using non-prescribed drugs, using non-prescribed dose regimen, can cause polysubstance dependence, or combined drug intoxication which may lead to deaths.
Table To avoid an excessively long list, the table below only lists recreational drug combinations that are not patent medicine.
Drug 1 Drug 2 Drug 3 Drug 4 Polysubstance slang,or brand name Intoxication name Comment Any dissociative Any dissociative Void flip Void flippingAny dissociative DMTDime bar, angel flipDimension flipping, angel flipping Any depressant Any stimulant Speedball, powerball, over and under Powerballing, speedballing Any pharmaceutical Any pharmaceutical Polypharmacy Pharming Polypharmacy is most commonly defined as the use of five or more medications daily by an individual. However, the definition of polypharmacy is still debated and can vary from two to 11 concurrent medications. Any drug Cannabis Amp joint Any β-Carbolinecontaining plant (e.g.Banisteriopsis caapior Peganum harmala) DMT Ayahuasca, Changa Ayahuasca is drunk. Changa is smoked or vaped. Any antiretroviral drug Black tar heroin Whoonga, Nyaope Widespread use in South Africa. Whoonga is classically reputed to be a combination of heroin with antiretroviral drugs such as ritonavir and/or efavirenz, often combined with additional drugs such as cannabis or hashish, methamphetamine and/or methaqualone Any Benzodiazepine Psilocybin or psilocybin mushrooms Warp Trip Warping / Warp Tripping When taken recreationally, a combination of benzodiazepine and psilocybin may soothe some of the more extreme negative effects often experienced during the peak and comedown phases of a psychedelic trip. Although benzodiazepines do not counteract the hallucinogenic and euphoric sensations caused by Psilocybin (commonly found in psilocybin mushrooms), they are sometimes administered by medical professionals to mitigate symptoms of a "bad trip." This practice helps to gradually relieve overactive sensory responses and induces relaxation in the individual, easing their mental state. Any deliriant or diphenhydramine MDMA or Psychedelics Nightmare flip Nightmare flipping 2C-B or the closely related 2C-x LSD or any of the Lysergamides MDMA or any Empathogen-entactogen Ali Flip Ali FlippingThis combination starts as a classic candyflip and ends in a Nexus flip. The LSD is taken first, followed by the MDMA 4 hours later and then 2C-B is taken 2 hours after the MDMA (i.e. 6 hours after the LSD ).
MDMA can be replaced by 6-APB, 5-APB, 6-MAPB or 5-MAPB, in this case the Empathogen is taken 2 hours after the LSD, while 2C-B may be replaced by 2C-C, 2C-D or 2C-B-FLY.
This combination's goal is to prolong the empathogenic effects of MDMA and the psychedelic effects of LSD. The idea is to be able to experience an enhanced "Candyflipping" with a twist in the end and a smoother comedown. The whole experience is long-lasting and can be too intense for some individuals as all of these molecules synergize and potentiate each other. 2C-B or the closely related 2C-x Mescaline MDMA or any Empathogen-entactogen 2C-B MDMA Nexus flip Nexus flipping The MDMA is often taken first and the 2C-B after the end of the MDMA peak (h+2/h+2.½).