The Central Missouri Activities Conference, or CMAC, is a high school athletic conference comprising large-size high schools located in Mid-Missouri. The conference members are located in Boone, Camden, Cole, and Pettis counties.

Members Founded in 2020, the Central Missouri Activities Conference consisted of seven high schools at its founding. The conference consists of Class 5 and Class 6 schools (in boys' basketball), the two largest classes in Missouri. Camdenton High School became a member at the beginning of the 2024-2025 Academic year after the demise of the Ozark Conference.

School Nickname Colors City County Type Year Joined Battle Spartans Columbia Boone Public 2020 Camdenton Lakers Camdenton Camden Public 2024 Capital City Cavaliers Jefferson City Cole Public 2020 Helias Catholic Crusaders Jefferson City Cole Private/Catholic 2020 David H. Hickman Kewpies Columbia Boone Public 2020 Jefferson City Jays Jefferson City Cole Public 2020 Rock Bridge Bruins Columbia Boone Public 2020 Smith-Cotton Tigers Sedalia Pettis Public 2020

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