James McGinnis may refer to:
James D. McGinnis (1932–2009), American politician, lieutenant governor of Delaware James Randy McGinnis (1957–2019), American professor of science education J. Michael McGinnis (born 1944), American physician and epidemiologist James Anthony Bailey (1847–1906), né McGinnis, American owner and manager of several 19th-century circuses Larry McGinnis (James Laurence McGinnis, 1899–1948), American football player