The 2022 Challenger de Buenos Aires was a professional tennis tournament played on clay courts. It was the eleventh edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Buenos Aires, Argentina between 26 September and 2 October 2022.

Singles main-draw entrants Seeds Country Player Rank1 SeedFederico Coria711Daniel Altmaier972Juan Pablo Varillas1023Camilo Ugo Carabelli1194Facundo Bagnis1205Felipe Meligeni Alves1446Santiago Rodríguez Taverna1597Yannick Hanfmann1708 1 Rankings are as of 19 September 2022.

Other entrants The following players received wildcards into the singles main draw: Román Andrés Burruchaga Lautaro Midón Juan Bautista Otegui

The following player received entry into the singles main draw using a protected ranking: Sumit Nagal

The following player received entry into the singles main draw as a special exempt: Mariano Navone

The following players received entry into the singles main draw as alternates: Facundo Díaz Acosta Gonzalo Villanueva

The following players received entry from the qualifying draw: Nicolás Álvarez Hernán Casanova Facundo Juárez Wilson Leite Ignacio Monzón Thiago Seyboth Wild

The following player received entry as a lucky loser: Carlos Sánchez Jover

Champions Singles

Juan Manuel Cerúndolo def. Camilo Ugo Carabelli 6–4, 2–6, 7–5.

Doubles

Guido Andreozzi / Guillermo Durán def. Román Andrés Burruchaga / Facundo Díaz Acosta 6–0, 7–5.

References