The Mokelumne River is a river that flows from the Sierra Nevada mountains in northern California, USA.
Mokelumne may also refer to: The Mokelumne Wilderness, a federally designated wilderness area named after the river Mokelumne Hill, California, a town named after the river The Mokelumne Aqueduct, a water conveyance system that is supplied by the river The Mokelumne River AVA, an American Viticultural Area named after the river