Dipierro, Di Pierro, di Pierro, or DiPierro is an Italian surname. Notable people with this surname include:

Gaetano Di Pierro (born 1948), Italian bishop Luca Dipierro, Italian animator and illustrator Nahuel di Pierro (born 1984), Argentine opera singer Ray DiPierro (1926–2014), American football player Serena Dipierro, Italian mathematician

See also Pierro (surname), people with this surname