25T7-NBOMe, also known as 2C-T-7-NBOMe or NBOMe-2C-T-7 as well as N-(2-methoxybenzyl)-4-propylthio-2,5-dimethoxyphenethylamine, is a serotonergic psychedelic of the 25-NB (NBOMe) family. It is the NBOMe analogue of 2C-T-7. The compound has been sold as a designer drug.
Use and effects The active dose range and route of 25T7-NBOMe do not appear to have been described.
Interactions
Pharmacology Pharmacodynamics + Target Affinity (Ki, nM) 5-HT1A 1,800–>10,000 5-HT1B 1,902–>10,000 5-HT1D 1,349–2,176 5-HT1E >10,000 5-HT1F 5-HT2A 0.68–1.16 (Ki)7.42–260 ()41–173% () 5-HT2B 2.16–2.3 (Ki)310 ()14% () 5-HT2C 1.33–6.4 (Ki)19.1 ()95% () 5-HT3 >10,000 5-HT4 5-HT5A >10,000 5-HT6 62.4–68.8 5-HT7 >10,000 α1A 340–490 α1B >10,000α1D 1,429 α2A 226–360 α2B 603α2C 479 β1 β2 4,266β3 2,163 D1 4,100 D2 1,000 D3 153–1,400 D4 186D5 H1 403–1,200 H2 1,000H3–H4 M1–M5 I1 σ1 19.1σ2 22.6 MOR 944 DOR >10,000 KOR 148 1,000 (Ki) (mouse)88–90 (Ki) (rat)2,100 () (mouse)550 () (rat)>10,000 () (human)68% () (mouse)52% () (rat) 1,514–3,200 (Ki)17,000 () () 3,700–>10,000 (Ki)34,000 () () 2,344 (Ki)55,000 () () Notes: The smaller the value, the more avidly the drug binds to the site. All proteins are human unless otherwise specified. Refs:
25T7-NBOMe acts as a highly potent and selective agonist of the serotonin 5-HT2 receptors. Its affinities and activities at a variety of other receptors and transporters have also been described.
History 25T7-NBOMe was first described in the scientific literature by 2012.
Society and culture Legal status Canada 25T7-NBOMe is a controlled substance in Canada under phenethylamine blanket-ban language.
See also 25-NB 25T-NBOMe 25T2-NBOMe 25T4-NBOMe
References
External links 25T7-NBOMe - Isomer Design