Admiral O'Brien may refer to:

Donat Henchy O'Brien (1785–1857), British Royal Navy rear admiral Edward O'Bryen (sometimes O'Brien) (c. 1753–1808), British Royal Navy rear admiral James O'Brien, 3rd Marquess of Thomond (1769–1855), British Royal Navy admiral John O'Brien (admiral) (1918–1996), Canadian Forces vice admiral William O'Brien (Royal Navy officer) (1916–2016), British Royal Navy admiral