Michalopoulos is a surname. Notable people with the surname include:
Andreas Michalopoulos (born 1949), Greek footballer Athanasios Michalopoulos (born 1973), Greek beach volleyball player George Michalopoulos, Greek-American pathologist Giannis Michalopoulos (1927–2016), Greek actor Ilias Michalopoulos (born 1985), Greek footballer Panos Michalopoulos (born 1949), Greek actor Tom Michalopoulos (1950–2021), Greek-born Canadian entrepreneur