Desbordes is a surname. Notable people with the surname include:
Drew Desbordes, better known as Druski (born 1994), American comedian Gustave Borgnis-Desbordes (1839–1900), French general Henri Desbordes (died c.1722), French printer in Amsterdam Marceline Desbordes-Valmore (1786–1859), French poet and novelist Mario Desbordes (born 1968), Chilean politician and police officer Michèle Desbordes (1940–2006), French writer