Isom is a surname and occasionally a given name. Notable people with the name include:
Anne Williams-Isom (born 1967), American government official, academic, lawyer, and nonprofit executive Cedric Isom (born 1984), American-Rwandan basketball player Daniel Isom (born 1967), American academic and police officer Harriet Winsar Isom (born 1936), American foreign service officer Lori L. Isom, American pharmacologist Mary Frances Isom (1865–1920), American librarian Mike Isom (born 1948), American football coach Mo Isom (born 1989), American soccer player Ray Isom (born 1965), American football player Rickey Isom (born 1963), American football player Sarah McGehee Isom (1854–1905), American orator