Orfila may refer to:
Surname Alejandro Orfila (1925–2021), Argentine diplomat, international functionary, and later winemaker Alejandro Orfila (footballer) (born 1976), Uruguayan football manager and former player Arnaldo Orfila Reynal (1897–1998), Argentine-Mexican publisher Mathieu Orfila (1787–1853), Spanish-French toxicologist and chemist Pedro Orfila (born 1988), Spanish footballer
Second surname Rodolfo Solano Orfila (1929–1997), Costa Rican economist and politician
Given name Orfila Bardesio (1922–2009), Uruguayan poet and educator
See also Trupanea orfila, species of fruit fly Orfila Vineyards and Winery, in the U.S. state of California