Kekana is a South African surname. Notable people with the surname include:
Grant Kekana (born 1992), South African footballer Hlompho Kekana (born 1985), South African footballer Johannes Kekana (born 1972), South African long-distance runner Pinky Kekana (born 1966), South African politician Steve Kekana (1958–2021), South African singer and songwriter