Omole is a Nigerian surname. Notable people with the surname include:
Augustine Omole (1955–2021), Nigerian bishop Faith Omole (born 1992), British Nigerian actress and playwright Idowu Bamitale Omole (born 1954), Nigerian educator Lawrence Omole (1915–2008), Nigerian entrepreneur Olugbenga Omole (born 1972), Nigerian politician, legislator, football administrator, and farmer
See also Leucotmemis omole a moth of the subfamily Arctiinae