The 2019 Midwestern State Mustangs football team represented Midwestern State University in the 2019 NCAA Division II football season. They were led by head coach Bill Maskill, who is in his 18th season at Midwestern State. The Mustangs played their home games at Memorial Stadium and were members of the Lone Star Conference.
Schedule Midwestern State announced their 2021 football schedule on March 6, 2019.
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