Citramalic acid is the organic compound with the formula HO2CCH2C(CH3)(OH)CO2H. A chiral compound, it is related structurally to malic acid.
Synthesis and reactions Citramalic acid is the hydrated derivative of mesaconic acid, The hydration is catalyzed by mesaconyl-C4-CoA hydratase: HO2CCH=C(CH3)CO2H + H2O → HO2CCH2C(CH3)(OH)CO2H The same conversion can be achieved in vitro.
The enzyme (S)-citramalyl-CoA lyase converts citramalyl-CoA to acetyl-CoA and pyruvate.
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