Protopopescu is a Romanian surname. Notable people with the surname include:
Atanasie Protopopescu (1900–1991), Romanian athlete and sports official Dana Protopopescu, Romanian pianist Dragoș Protopopescu (1892–1948), Romanian writer, poet, critic, and philosopher Luca Protopopescu (born 2016), French chess player Ștefan Protopopescu (1886–1929), Romanian officer and aviation pioneer