Southend by-election may refer to several by-elections in the town of Southend, England:
1927 Southend by-election, after Rupert Guinness was elevated to the Lords (won by Gwendolen Guinness) 1959 Southend West by-election, after the death of Henry Channon (won by Paul Channon) 1980 Southend East by-election, after the death of Stephen McAdden (won by Teddy Taylor) 2019 Milton by-election, in Southend council's Milton ward, after the death of Julian Ware-Lane 2022 Southend West by-election, after the killing of David Amess