Gurule is a surname. Notable people with the surname include:
Delfina Gurule (1883–1979), owner of Delfina Gurule House in Albuquerque, New Mexico, U.S. Jimmy Gurulé (born 1951), American attorney, academic and government official Martin Gurule (1969–1998), American prisoner Luis Gurule (born 1993), American Mixed Martial Artist