The mixed 4 × 100 metre freestyle relay S14 swimming event for the 2020 Summer Paralympics took place at the Tokyo Aquatics Centre on 28 August 2021.
Final Rank Lane Nation Swimmers Time Notes 4 Reece DunnBethany FirthJessica-Jane ApplegateJordan Catchpole 3:40.63 WR 3 Ricky BetarBenjamin HanceRuby StormMadeleine McTernan 3:46.38 OC 6 Gabriel BandeiraAna Karolina SoaresDébora CarneiroFelipe Vila Real 3:51.23 AM 4 7 Dai TokairinNaohide YamaguchiKasumi FukuiMami Inoue 3:57.18 AS 5 2 Tang Wai-lokChan Yui-lamHui Ka ChunCheung Ho Ching 4:00.86 5 Mikhail KuliabinViacheslav EmeliantsevOlga PoteshkinaValeriia Shabalina
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