The sixteenth edition of LOS40 Music Awards was held at the Velòdrom Illes Balears in Palma de Mallorca, on November 12, 2021. Ed Sheeran was the most-awarded artist at the ceremony, winning a total of four awards for Best Artist, Best Song and Video (for "Bad Habits"), and Best Live Act.
Performers +List of musical performances at the LOS40 Music Awards 2021 Artist(s) Song(s) Hombres G "Voy a pasármelo bien" Dani Martín "No, no vuelve""Son sueños" Lola Índigo "Santería""La Niña de la Escuela" LeivaXimena Sariñana "Histéricos" Ed Sheeran "Bad Habits""Shivers" Griff "One Night" Pablo AlboránAitanaÁlvaro de Luna "Llueve sobre mojado" Justin Quiles "Loco" Nicki Nicole "Colocao" Sebastián Yatra "Tacones rojos""Pareja del Año""Chica Ideal" Marc Seguí "Tiroteo (Remix)" Ana MenaRocco Hunt "Un beso de improviso""A un paso de la luna" Melendi "La boca junta" Aitana "Berlín""Mon Amour (Remix)" Beret "Desde cero" Álvaro Soler "Magia" TopicA7S "Breaking Me""Your Love (9PM)"
On October 24, 2021, Ed Sheeran announced that he had tested positive for COVID-19 and would be fulfilling all subsequent commitments remotely. The singer completed his quarantine by November 2 and was cleared to resume in-person promotional activities for =, including his appearance at Los40.
Winners and nominees Nominees were revealed on October 5, 2021, at an announcement dinner held in Ibiza. C. Tangana and Ed Sheeran were the most-nominated artists overall, as well as in the national and international sections respectively, with four nominations each. Rauw Alejandro and Sebastián Yatra led the Latin nominees with three nominations apiece. Sheeran won all four of his nominations and was the most-nominated artist of the night, while C.Tangana won two of his four. Winners are listed first and highlighted in bold.
+List of winners and nominees for the LOS40 Music Awards 2021 Spain Best Act Best New Act C. Tangana Ana Mena Pablo Alborán Vanesa Martín Lola Índigo Álvaro de Luna Marc Seguí Marlena Pole Belén Aguilera Best Album Best Song Pablo Alborán – Vértigo Sidecars – Ruido de fondo Dani Martín – Lo que me dé la gana Aitana – 11 Razones C. Tangana – El Madrileño Dani Martín – "Portales" C. Tangana, La Húngara & Niño de Elche – "Tú Me Dejaste De Querer" Álvaro de Luna – "Juramento eterno de sal" Pablo Alborán – "Si hubieras querido" Ana Mena & Rocco Hunt – "A un paso de la luna" Best Video Best Live Act Lola Índigo, Tini and Belinda – "La niña de la escuela" Pol Granch – "No pegamos" Sweet California – "Whisper" Álvaro Soler – "Magia" C. Tangana, Gipsy Kings, Nicolás Reyes & Tonino Baliardo – "Ingobernable" Aitana Marlon Bombai Dani Fernández Sidecars Del 40 Al 1 Artist Award Ana Mena Beret Dvicio Nil Moliner Omar Montes International Best Act Best New Act Ed Sheeran Imagine Dragons BTS The Weeknd Doja Cat Griff The Kid Laroi Olivia Rodrigo 24kGoldn Måneskin Best Album Best Song Olivia Rodrigo – Sour Justin Bieber – Justice Sam Smith – Love Goes The Kid Laroi – F*ck Love 3+: Over You Ariana Grande – Positions Ed Sheeran – "Bad Habits" BTS – "Dynamite" Olivia Rodrigo – "Drivers License" The Kid Laroi – "Without You" Lil Nas X – "Montero (Call Me by Your Name)" Best Video Best Live Act Ed Sheeran – "Bad Habits" Lil Nas X – "Montero (Call Me by Your Name)" Dua Lipa – "We're Good" Coldplay – "Higher Power" Camila Cabello – "Don't Go Yet" Ed Sheeran Shawn Mendes Imagine Dragons Justin Bieber Dua Lipa Best Dance Act Topic Majestic Riton x Nightcrawlers Purple Disco Machine David Guetta Latin Best Act Best New Act Sebastián Yatra Camilo Tini Danna Paola Becky G Nicki Nicole Nathy Peluso Mariah Angeliq María Becerra Nio García Best Urban Act Best Song Rauw Alejandro J Balvin Justin Quiles Jhay Cortez Karol G Rauw Alejandro – "Todo de Ti" Bad Bunny and Jhay Cortez – "Dakiti" Sebastián Yatra and Myke Towers – "Pareja del Año" Camilo – "Vida de rico" Farruko – "Pepas" Best VideoSebastián Yatra and Myke Towers – "Pareja del Año" Karol G, Anuel AA and J Balvin – "Location" Bad Bunny and Rosalía – "La Noche de Anoche" Rauw Alejandro – "Todo de Ti" J Balvin and Skrillex – "In da Getto" Golden Music Award Hombres GRafael Nadal
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