The government of Vietnam prepared for the COVID-19 pandemic as early as the first cases in China emerged in December 2019, and pursued a zero-COVID strategy until September 2021.

In January 2020, Vietnam's Prime Minister Nguyễn Xuân Phúc ordered measures to prevent and counter the spread of the disease into Vietnam, as well as to warn Vietnamese citizens to avoid visiting areas with outbreaks. During the same year, authorities enacted several lockdowns in response to localised outbreaks. Contact tracing and social distancing measures were rolled out, and Vietnam's communications and propaganda apparatus dispelled information about the disease. In 2021, a vaccination programme began, whilst outbreaks in Ho Chi Minh City and Hanoi prompted the government to introduce further lockdowns, which were ultimately lifted due to their economic and social impacts, and continued spread of the Delta variant.

Reception for the government's response was mixed. While the government's decisiveness and effectiveness in controlling the disease during 2020 received high public approval and international recognition, outbreaks the following year and low vaccine uptake signalled a decline in public trust. The human rights implications of some interventions attracted controversy, whilst the Việt Á corruption scandal related to COVID-19 testing kits led to several senior officials resigning, being removed from office, or facing prosecution and imprisonment for corruption.

Advance preparations According to Kidong Park, World Health Organization representative to Vietnam, the first risk assessment exercise was conducted by the Vietnamese in early January – soon after cases in China started being reported. On 3 January 2020, the day before the WHO said there was a cluster of cases in Wuhan, Vietnam tightened control at the Vietnam-China border. The Ministry of Health held a meeting with the WHO and the US Centers for Disease Control and Prevention (CDC) as early as 15 January, weeks before many other countries even started strategizing. These combined efforts of quick action and effective testing helped slow the spread of the virus in its earliest stages.

Regional COVID-19 prevention task forces were established, and these groups were prepared for deployment by the Ministry of Health to provincial treatment sites. In view of an assumed increased infection risk among medical staff as had been seen during the SARS outbreak, personal protective equipment was stockpiled, and infection control measures were heightened at hospitals.

On 23 January, Vietnam confirmed its first case. Shortly afterward, the Prime Minister Nguyễn Xuân Phúc ramped up Vietnam's response by issuing an urgent document to ministries, provinces, and broadcasting agencies addressing the dangerousness of the virus and the need for measures to prevent local transmission. On 24 January, just one day after the first cases, the Civil Aviation Administration of Vietnam ordered the cancellation of all flights from and to Wuhan. As Vietnam celebrated the Tết holiday, the Prime Minister declared war on the coronavirus. "Fighting this epidemic is like fighting the enemy", he said at an urgent Communist Party meeting on 27 January.

On 31 January, infectious disease expert Nguyễn Thanh Long was appointed as deputy Minister of Health and later as Minister of Health, he served as one of the main government advisors regarding the pandemic. On the same day, Vietnam implemented stricter measures, suspending inbound and outbound flights related to the epicenters in China, restricting tourists, dosing train connection, and suggested people suspend trade and other exchange activities between the two countries. Such a decision to limit cross-border transactions with China indicated the extent of the government's commitment to prioritizing public health.

In January, the government also issued the first National Response Plan and assembled the National Steering Committee (NSC). The committee, led by Deputy Prime Minister Vũ Đức Đam with representation from 14 ministries and sectors, the National Assembly, media, and information technology companies will command and control the country COVID-19 response. Vietnam has 63 provincial health departments, an approximately 600 district health centers and more than 11,000 primary health stations. While hospitals provide medical care for COVID-19 patients, the primary health stations are responsible for prevention activities and total support for hospitals. In fact, an approximately 97,000 health officers at community level in these sections serve as the workers to provide information, advice, guidance, and isolation facilities if needed.

In February 2020, Vietnamese Ministry of Education and Training suspended all school activities across the country until the end of March as part of quarantine measures against the spreading of the virus, and later extended this till the middle of April until further notice. Aggressive measures were also taken to combat possible outbreaks, from 14 days quarantine to restriction of outdoor activities (some sources believe it was more than 20 to 40 days under quarantine), the Vietnam People's Armed Forces also takes part on patrolling and controlling measures. Sixty-eight military camps with a capacity of 40,000 people were set up to receive people ordered into quarantine.

The first case of mass quarantine in Vietnam took place on February 12 in Sơn Lôi, Vĩnh Phúc, a community of 10,000 people for 20 days over seven coronavirus cases – the first large-scale lockdown known outside China. Aggressive preventive action enabled Vietnam to contain the earlier outbreaks, with only 16 cases, all recovered, by the end of February.

On the night of 6 March, when the 17th case was reported in Hanoi, the city held an urgent meeting, then coordinated with related ministries — including the Ministry of Health, Ministry of Public Security, and Ministry of Transportation — to prevent the virus from spreading to the community. Thanks to this effective coordination, public health measures such as aggressive contact tracing, mandatory quarantine, and sterilization of surfaces were taken immediately, which enabled the government to stop community transmission and lift the large-scale lockdown still common in many Southeast Asian nations at that time. On March 7, Hanoi locked down Trúc Bạch Street, where the patient resided along with 66 households and 189 people. The quarantine was lifted on March 20 after no new cases were reported after testing. Imported cases from Europe motivated the government to intensify its border control measures, reducing international flights, suspending visa waiver for certain European countries.

When the Bạch Mai Hospital in Hanoi became a coronavirus hotspot with dozens of cases in late March, the authorities imposed a lockdown on the facility and tracked down nearly 100,000 people related to the hospital, including medics, patients, visitors and their close contacts.

Lockdowns April nationwide isolation

On 31 March 2020, the Vietnamese government ordered a nationwide isolation of 15 days from 1 to 15 April. From 16 April, local airlines could raise the number of domestic flights, which were subsequently further increased on 23 April and again on 29 April.

On 23 April 2020, Vietnamese government lifted social isolation rules, subsequently allowing re-opening of non-essential services including restaurants. On the same day, schools across the country could be re-opened, with dates varying per each province and city case.

Everyone who enters Vietnam from abroad, however, continued to be quarantined upon arrival for 14 days. From 23 April, plans for repatriation flights to bring Vietnamese citizens abroad back to Vietnam were re-newed, with an initial plan for 13 flights. Among the flights conducted was notably the first-ever direct flight in history operated by Vietnam Airlines from Vietnam to the United States on 7 May.

From 9 May, cinemas were reopened. On 11 May, Vietnamese government started a nationwide tourism campaign, named 'Vietnamese travel Vietnam', to increase domestic demand for travelling and promote domestic tourism.

Da Nang lockdown

In late-July 2020, Vietnam was placed on high alert after the government confirmed dozens of community infections, the first since April, all in or around Da Nang.

On 27 July, the government made the decision to evacuate 80,000 people from Da Nang. The government said the process would take four days with domestic airlines operating approximately 100 flights daily from Da Nang to 11 cities around the country.

On the same day, the Da Nang Municipal People's Committee announced restrictions applicable for 15 days, starting from 28 July. Six districts in quarantine area include: Hai Chau, Thanh Khe, Son Tra, Ngu Hanh Son, Cam Le, and Lien Chieu District with more than one million people requested to stay at home and only go out in case of extreme necessity such as buying food, medicine, seeking essential goods and services, and medical emergencies. All educational and non-essential services in the city was closed. Face masks were mandated in public and people were ordered to frequently wash their hands with soap or alcoholic sanitisers. Gatherings of more than two people in public are disallowed and maintenance of a minimum distance of 2 meters is required. All types of public transport were halted and personal vehicles were heavily restricted. The Da Nang Department of Health was asked to promptly organize epidemiological investigation, contact-tracing in areas related to the confirmed cases, and massive testing to early detect infection sources and high-risk cases.

The rural district of Hoa Vang was the last district to be quarantined, starts from 13:00, 28 July 2020. On 31 July, the neighboring city of Hội An were also placed under quarantine for 15 days after at least 4 people tested positive with COVID-19.

The authorities also decided to lockdown four hospitals: Da Nang C Hospital, Da Nang Hospital, Da Nang Orthopedic and Rehabilitation Hospital and Hoan My Hospital where the patients visited just before they were confirmed positive for COVID-19.

According to the regulation of the Ministry of Transport issued on 27 July to prevent the COVID-19 pandemic:

On 12 August, Da Nang has decided to continue social distancing for another two weeks when the number of cases in the community still shows no signs of stopping. The local government also issued "shopping coupons" for residents, each family will be given five coupons to use within 15 days, in order to prevent large gatherings at markets.

July 2021–present

From 9 February to 1 March 2021, facing an increase in cases, Ho Chi Minh City closed down spas, wedding halls, cinemas, clubs and other entertainment venues. On 25 May, entertainment venues and public spaces were again closed. On 31 May, strict social distancing measures were again imposed in all of Ho Chi Minh City, closing down all non-essential services. Remote work was advised and no dine-in was allowed in restaurants. On 9 July 2021, all of Ho Chi Minh City was placed into hard lockdown. In and out movements outside the city, excepts goods, were stopped. Fines were imposed for venturing outside without a valid reason such as buying foods. On 19 July, stricter restrictions were imposed forcing all restaurants, markets and businesses to be closed down. On 26 July, a night curfew was ordered, forbidding all movements after 6pm. This was later extended to 1 August. Hanoi was also placed under lockdown on 23 July.