Don or Donald Nichols or Nicholls could refer to:

Donald Nichols (American football) (1901–1978), American college football player and attorney Donald Nichols (spy) (1923–1992), U.S. Air Force officer Donald G. Nichols (born 1931), member of the Florida House of Representatives Don Nichols (1924–2017), American motorsport entrepreneur Donald Nicholls, Baron Nicholls of Birkenhead (1933–2019), British barrister and Law Lord Don Nicholls (1936–2023), Australian rules footballer

See also Don Nickles (born 1948), former U.S. senator from Oklahoma