Keyworth is a surname. Notable people with the surname include:
Andrew Stanley Keyworth (1923–1996), New Zealand mariner George A. Keyworth II (1939–2017), American physicist Gwyneth Keyworth (born 1990), Welsh actress Henry Keyworth Raine (1872–1934), British portraitist John Keyworth (1859–1954), British archer John Keyworth Boynton (11918–2007), British legal officer Jon Keyworth (born 1950), American football player Ken Keyworth (1934–2000), British football player Leonard James Keyworth (1893–1915), English recipient of the Victoria Cross Mark Keyworth (1948–2014), English rugby player Sarah Keyworth (born 1993), English stand-up comedian