The Women's 400 metre freestyle S8 event at the 2020 Paralympic Games took place on 31 August 2021, at the Tokyo Aquatics Centre.

Final

Rank Lane Name Nationality Time Notes 4 Morgan Stickney 4:42.39 5 Jessica Long 4:43.41 3 Xenia Francesca Palazzo 4:56.79 4 6 Nahia Zudaire Borrezo 5:07.67 5 2 Mira Jeanne Maack 5:12.82 6 8 Vendula Dušková 5:20.71 7 7 Amalie Vinther 5:22.44 8 1 Mariia Pavlova 6:00.36

References