This is an incomplete list of unsolved murders in the United Kingdom that were committed between 2000 and 2009. Victims believed to have been killed by the same perpetrator(s) are grouped together below.

Year Victim(s) Location of body or bodies NotesJanuary 2000Lola ShenkoyaBody not foundShenkoya, a 27-year-old computing graduate, disappeared from Ealing Broadway on 3 January 2000. Police believe her to have been killed by serial sex offender and suspected serial killer Andrzej Kunowski, who murdered a 12-year-old girl nearby in 1997 and is also the prime suspect in the murder of Elizabeth Chau, who disappeared from almost the exact same location as Shenkoya some months earlier. Kunowski was questioned over both disappearances, but no concrete evidence was found to link either of them to him before he died in prison in 2009.January 2000Roger OrmsbyManchester35-year-old Ormsby's body was in the driver's seat of the businessman's BMW when it was discovered burning in an alley in Whalley Range on 5 January 2000. He had been shot in the back of his head.January 2000Gabriel EgharevbaManchester17-year-old Egharevba was shot when he and a friend were being chased by two men on motorcycles whilst riding their bicycles through Longsight on 12 January 2000. Detectives thought it was a case of mistaken identity.January 2000Martin LavelleAttacked in Willesden, London, died in hospital in Oxford48-year-old Lavelle, an Irishman living in Willesden, left a bar close to his bedsit in Meyrick Road at nighttime on 4 January 2000 and was assaulted. A friend then saw him lying in that road and took him home, where he was found collapsed two days later by friends who had broken in after he had failed to answer his door.

Following his admission to the nearby Central Middlesex Hospital, Lavelle's condition deteriorated enough for him to require an intensive care bed, but the apparent unavailability of such beds in London led to him being moved to a hospital in Oxford on 17 January. Severe head injuries were the cause of the mugging victim's death on 22 January.January 2000Lee KingMiddlesbroughKing, a 32-year-old petty criminal described as a "likable rogue", was shot dead in Park End on 28 January 2000. A love rival was acquitted of his murder in February 2001. The suspect had also been charged with the murder of Kevin Richardson in the same area of Middlesbrough in 1993, but the charge over that death was dismissed at the magistrates' court level owing to lack of evidence.February 2000Bill MalcolmManor Park, LondonMalcolm, a 46-year-old with convictions for sexual offences against children, was shot in the head on the doorstep of his Manor Park flat in a suspected case of vigilantism on 17 February 2000.March 2000Michael EnnisLiverpool27-year-old Ennis was struck, fell to the pavement and suffered a fractured skull outside the Anglesea pub on Beresford Road, Liverpool, on 2 March 2000. He died at Aintree University Hospital after being transferred there for neurosurgery, having initially been taken to another hospital in Liverpool, and his death was due to edema and necrosis of the brain. A man stood trial for manslaughter the following November and was acquitted.March 2000Brian HarrisBrixton, London25-year-old Harris was shot dead at his home in Brixton on 11 March 2000. The case was probed by Operation Trident, a Metropolitan Police unit dealing with black-on-black crime.March 2000Craig MirfieldLeedsMirfield, a 34-year-old car dealer, was shot in his car in Gipton, Leeds, on 15 March 2000 while trying to drive away from a gunman. A man was prosecuted for Mirfield's murder, but his trial ended early due to reservations about the reliability of the two main witnesses.March 2000Terry GibsonBarnet, London53-year-old Gibson, a landscape gardener with business interests, was shot dead outside his home in Moxon Street, Barnet, on 16 March 2000. Police believed the crime to have been a contract killing.April 2000David DannAttacked in Blackheath, London, died in hospital24-year-old Dann was shot from behind just after midnight on 4 April 2000. He and a friend he was with then separated and the offender pursued Dann, who was struck by a total of three bullets before being pronounced dead in hospital at 12:46 a.m.April 2000Sarah BenfordBody not found14-year-old Benford vanished in April 2000 and although her body has never been found, her disappearance is being treated as a murder. Benford was described by police as a "troubled teenager"; she was in care and ran away from Welford House children's home in Welford Road, Northampton on 4 April. She visited her mother in Kettering on 6 April and there were various other sightings of her in Kettering that day. In 2003, a number of people were arrested and properties were searched, but then the investigation stalled. In 2016, police searched woods near Warkton in Northamptonshire – an area known to have been used by acquaintances of Benford for storing stolen goods and other items.May 2000Nicola RayBody not foundRay has not been seen since she parted company with a friend in Basildon, Essex, in the early hours of 2 May 2000 following a night out. She was 29 or 30 years old at the time. Ray's fiancé was arrested twice on suspicion of her murder, but neither arrest led to any charges.May 2000Frank McPheeMaryhill, GlasgowMcPhee, a 51-year-old gangster himself twice acquitted of murder, was shot by a sniper in a block of flats opposite his own as he returned home on 10 May 2000.May 2000Cheryll GroverNewbury, BerkshireGrover, 21, was last seen alive by a visitor to her home on Audley Close, Turnpike, Newbury, at 10:30 p.m. on Friday 12 May 2000. She spoke to a friend on the telephone at 2:35 a.m. on Saturday 13 May, but efforts made by her estranged husband to contact her later that same day came to nothing. Concerned for Grover's welfare, he and his mother visited Grover's home at 3:30 p.m. and he climbed the drainpipe to reach the first floor bedroom window. Inside, Grover was found dead in her bedroom, having been strangled with a dressing gown cord. Police suspected that she had been selling drugs from her home and an appeal led to a number of people coming forward. A 32-year-old man was arrested but released without charge.