The 2021 Quito Challenger was a professional tennis tournament played on clay courts. It was the 22nd edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Quito, Ecuador between 13 and 19 September 2021.

Singles main-draw entrants Seeds Country Player Rank1 SeedAndrej Martin1221Emilio Gómez1612Mario Vilella Martínez1703Renzo Olivo2154Juan Pablo Ficovich2545Facundo Mena2626Thiago Agustín Tirante2687Roberto Quiroz2948 1 Rankings are as of 30 August 2021.

Other entrants The following players received wildcards into the singles main draw: Álvaro Guillén Meza Antonio Cayetano March Gian Carlos Rodríguez

The following players received entry from the qualifying draw: Luca Castelnuovo Alexis Gautier Alejandro Gómez Christian Langmo

Champions Singles

Facundo Mena def. Gonzalo Lama 6–4, 6–4.

Doubles

Alejandro Gómez / Thiago Agustín Tirante def. Adrián Menéndez Maceiras / Mario Vilella Martínez 7–5, 6–7(5–7), [10–8].

References