1V-LSD, also known as 1-valeryl-LSD or by the nickname Valerie, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD). It is an analogue of LSD and is thought to act as a prodrug of LSD. The drug has been encountered as a novel designer recreational drug.
Use and effects
1V-LSD has been sold in the form of blotter containing 150μg per tab. Its effects are said to be comparable to 100 to 120μg 1P-LSD or 1cP-LSD, but with a longer duration. On the other hand, other sources report that 1V-LSD has a shorter duration than LSD of 6 to 8hours.
Interactions
Pharmacology Pharmacodynamics As demonstrated with other N-acylated derivatives of LSD, 1V-LSD is believed to serve as a prodrug for LSD but may also act directly as a weak partial agonist at the serotonin 5-HT2A receptor.
A head-twitch response assay in mice found that 1V-LSD has a similar potency to 1P-LSD and 1cP-LSD, with behavioral effects also closely resembling these structural analogs.
Chemistry Synthesis 1V-LSD is the condensation product of valeric acid (pentanoic acid) and LSD, where the valeroyl group is substituted on the NH position of the indole moiety.
Detection Ehrlich's reagent is used to identify the presence of an indole moiety; the chemical backbone of the lysergamide and ergoline molecules. However, as with other N-acylated lysergamides, 1V-LSD reacts very slowly to Ehrlich reagent and may not give reliable results if the reagent isn't fresh.
Analogues Related compounds include 1B-LSD, 1cP-LSD, 1D-LSD, 1P-LSD, and AL-LAD, among others.
History 1V-LSD was first described in the scientific literature by 2022.
Society and culture Legal status
Canada 1V-LSD is not an explicitly nor implicitly controlled substance in Canada as of 2025.
Germany An amendment to the NpSG banned the sale of 1V-LSD in Germany in September 2022. Due to a interpunctation error in the actualised NpSG, the ban never took effect. The law was amended in March 2023, now banning 1V-LSD.
Poland
1V-LSD has been a controlled substance in Poland since 2024.
South Korea 1V-LSD was placed under legal control in South Korea in July 2022 on a temporary but renewable basis.Kim Chan-hyuk, Regulator names 1V-LSD as narcotic drug temporarily. Korea Biomedical Review, 5 July 2022
Sweden Since 2 March 2022, 1V-LSD has been under investigation in Sweden and may therefore soon become controlled.
United States 1V-LSD is not an explicitly controlled substance in the United States. However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.
See also Substituted lysergamide Lizard Labs
References
External links 1V-LSD - Isomer Design 1V-LSD - PsychonautWiki The Small & Handy 1V-LSD Thread - Bluelight Meet Valerie: LSD's Stealthy Sidekick (1V-LSD) - Tripsitter 1V-LSD - Lysergamide Psychedelics - TripSitter 1V-LSD: The New Wave of Acid - Sociedelic From 1V-LSD to 1D-LSD: The Evolution of Legal Lysergamides - Sociedelic