O'Laughlin is an Irish surname. Notable people with the surname include:
Cindy O'Laughlin, American politician and member of the Missouri Senate Jeanne O'Laughlin (1929–2019), co-founder of Barry University in Florida, USA John Callan O'Laughlin (1873–1949), publisher of the Army and Navy Journal
See also Ó Lochlainn O'Loughlin