Colomé or Colome may refer to:

People Abelardo Colomé Ibarra (born 1939), Vice President of the Council of State of Cuba Álex Colomé (born 1988), Dominican professional baseball pitcher Ana María López Colomé, Mexican biochemist Antoñita Colomé (1912-2005), Spanish film actress Jaime Colomé (born 1979), Cuban retired footballer Jesús Colomé (born 1977), former professional relief pitcher Jorge Colome (born 1958), Cuban sprint canoer Omar Félix Colomé (1932-2015), Argentine Roman Catholic bishop Pura López Colomé (born 1952), Mexican poet, translator Yoel Colomé (born 1982), Cuban football defender

Places Colomé, village and rural municipality in Salta Province in northwestern Argentina Colome, South Dakota, city in Tripp County, South Dakota, United States Sainte-Colome, commune in the Pyrénées-Atlantiques department in south-western France