Gretsch is a surname. Notable people with the surname include:
Émile Gretsch (1908–2004), Luxembourgish fencer Friedrich Gretsch (1856–1895), German American businessman and founder of Gretsch Joel Gretsch (born 1963), American actor Kendall Gretsch (born 1992), American triathlete, biathlete and cross-country skier Nikolay Gretsch (1787–1867), Russian grammarian Patrick Gretsch (born 1987), German cyclist