The 2021 Open Città della Disfida was a professional tennis tournament played on clay courts. It was the 21st edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Barletta, Italy between 23 and 29 August 2021.
Due to COVID-19 pandemic, the 2020 edition of the tournament was not held and the 2021 edition was rescheduled from the traditional dates in April.
Singles main-draw entrants
Seeds Country Player Rank1 SeedAndrej Martin1181Juan Manuel Cerúndolo1392Jay Clarke2193Tim van Rijthoven2594Matteo Viola2645Jack Draper2666Riccardo Bonadio2687Tseng Chun-hsin2708 1 Rankings are as of 16 August 2021.
Other entrants The following players received wildcards into the singles main draw: Jacopo Berrettini Emiliano Maggioli Luca Nardi
The following player received entry into the singles main draw using a protected ranking: Jeremy Jahn
The following player received entry into the singles main draw as an alternate: Francesco Forti
The following players received entry from the qualifying draw: Nicolás Álvarez Ryan Harrison Cristian Rodríguez Andrea Vavassori
Champions
Singles
Giulio Zeppieri def. Flavio Cobolli 6–1, 3–6, 6–3.
Doubles
Marco Bortolotti / Cristian Rodríguez def. Gijs Brouwer / Jelle Sels 6–2, 6–4.
References