The 2021–22 Coupe de France preliminary rounds, Hauts-de-France was the qualifying competition to decide which teams from the leagues of the Hauts-de-France region of France took part in the main competition from the seventh round.
A total of twenty teams qualified from the Hauts-de-France preliminary rounds. In 2020–21, US Boulogne progressed furthest in the main competition, reaching the round of 16 before losing to Canet Roussillon FC.
Draws and fixtures On 21 July 2021, the Oise district league published that 1024 teams from the region had entered the competition. Draws for the first two rounds were carried out separately by district leagues during July, with 818 teams in total entering at the first round stage, and 187 at the second round stage. The third round draw was published on 13 September 2021. The fourth round draw was published on 23 September 2021. The fifth round draw was made on 7 October 2021. The sixth round draw was made on 19 October 2021.
First round These matches were played on 28 and 29 August 2021.