Alexander Zverev defeated Andrey Rublev in the final, 6–2, 6–3 to win the men's singles tennis title at the 2021 Cincinnati Masters. It was his fifth Masters 1000 title and 17th career singles title on the ATP Tour.
Novak Djokovic was the reigning champion, but did not participate.
Seeds The top eight seeds receive a bye into the second round.
Draw
Finals
Top half
Section 1
Section 2
Bottom half
Section 3
Section 4
Qualifying
Seeds
Qualifiers
Lucky loser
Qualifying draw
First qualifier
Second qualifier
Third qualifier
Fourth qualifier
Fifth qualifier
Sixth qualifier
Seventh qualifier
References
External links Main draw Qualifying draw