Tillis is a surname. Notable people with the surname include:
Antonio D. Tillis, American academic administrator Darren Tillis (born 1960), American basketball player Frederick C. Tillis (1930–2020), American composer Iciss Tillis (born 1981), American basketball player James Tillis (born 1957), American boxer and actor Mel Tillis (1932–2017), American country music singer and songwriter Pam Tillis (born 1957), American country music singer and actress, daughter of Mel Rick Tillis (born 1963), American politician Thom Tillis (born 1960), American politician