The 2021–22 Coupe de France preliminary rounds, Nouvelle-Aquitaine was the qualifying competition to decide which teams from the leagues of the Nouvelle-Aquitaine region of France took part in the main competition from the seventh round.
A total of thirteen teams qualified from the Nouvelle-Aquitaine preliminary rounds. In 2020–21, US Lège Cap Ferret and Stade Poitevin FC progressed furthest in the main competition, reaching the round of 64 before losing to Aubagne FC and AS Monaco respectively.
Draws and fixtures On 13 July 2021, the league announced that a total of 689 teams had entered from the region. The first round would consist of 296 ties, featuring all teams from Régional 3 and below, plus 25 teams from Régional 2. The 45 exempted teams from Régional 2 and all 36 teams from Régional 1 entered at the second round stage. The 12 Championnat National 3 teams entered at the third round stage and the 4 Championnat National 2 teams entered at the fourth round stage.
First round These matches were played on 27, 28 and 29 August 2021. + First round results: Nouvelle Aquitaine Tie no Home team (tier) Score Away team (tier) 1. JS Chapelloise (11) 0–4 Montpon-Ménesplet FC (8) 2. ES Ligniac (11) 0–3 Limoges Landouge (7) 3. FC Smarves Iteuil (9) 3–0 Buslaurs Thireuil (10) 4. FC Loudun (10) 2–3 Espérance Availles-en-Châtellerault (10) 5. Antran SL (8) 1–1 FC Vrines (9) 6. Gati-Foot (10) 5–0 US Jaunay-Clan (10) 7. CO Cerizay (8) 1–1 US Envigne (9) 8. SL Cenon-sur-Vienne (11) 0–3 ES Louzy (10) 9. AS Périgné (12) 1–0 US Aulnay (9) 10. La Jarrie FC (10) 2–0 CS Beauvoir-sur-Niort (10) 11. Saint-Porchaire-Corme Royal FC (10) 0–3 Rochefort FC (7) 12. Us Vouillé 86 (8) 4–1 US Frontenay-Saint-Symphorien (9) 13. US Marennaise (8) 3–0 AS Aigre (9) 14. UAS Verdille (9) 1–1 Avenir Matha (7) 15. Val de Boutonne Foot 79 (10) 2–4 Oléron FC (8) 16. AS Maritime (8) 0–2 EFC DB2S (8) 17. US Pont l'Abbé d'Arnoult (11) 0–6 ES Celles-Verrines (8) 18. Canton Aunis FC (10) 3–3 CS Venise Verte (11) 19. FC Saint-Rogatien (10) 4–1 FC Saint-Fraigne (11) 20. FC Saint-Amant-de-Boixe (11) 0–5 US Pays Maixentais (8) 21. AS Cabariot (8) 0–0 AS Aiffres (7) 22. US La Crèche (10) 3–1 AS Saint-Christophe 17 (10) 23. AS Valdivienne (10) 2–1 FC Rouillé (9) 24. Avenir Nord Foot 87 (10) 5–2 US Vivonne (11) 25. FC Confolentais (9) 0–0 US Chasseneuil (10) 26. US Anais (11) 1–7 Tardoire FC La Roche/Rivières (8) 27. US Le Dorat (10) 0–6 FC Usson-Isle (9) 28. Entente Saint-Maurice-Gençay (14) 3–4 FC Fleuré (9) 29. Entente Nanteuil-Verteuil (12) 0–1 SC Verrières (9) 30. AS Civaux (11) 1–2 ASFC Vindelle (8) 31. AS Saint-Yrieix (9) 3–1 ES Château-Larcher (9) 32. Fontafie FC (11) 8–1 Espérance Saint-Bonnet-de-Bellac (11) 33. ES Montignac 16 (11) 0–2 OC Sommières Saint-Romain (11) 34. FC Chaillac Saillat (12) 0–2 Rochechouart OC (11) 35. ASPTT Limoges (11) 0–1 AS Lussac-les-Églises (11) 36. US Oradour-sur-Glane (11) 1–4 FC des 2 Vallées (9) 37. ES Ussel (9) 2–2 CS Boussac (8) 38. US Donzenac (7) 1–1 FC Sarlat-Marcillac (8) 39. FC Pays Arédien (11) 1–1 CA Chamboulive (9) 40. CS Allassac (9) 1–4 FC Argentat (8) 41. ES Nonards (8) 3–1 Entente Perpezac Sadroc (9) 42. USA Saint-Aigulin (10) 2–4 AS Puymoyen (8) 43. ES Mornac (10) 6–3 JS Abzac (11) 44. AJ Montmoreau (10) 3–1 AS Neuvic-Saint-Léon (10) 45. JS Basseau Angoulême (9) 3–6 FC Pays de Mareuil (8) 46. AS Soyaux (8) 2–3 US Chancelade/Marsac (9) 47. Union Saint-Médard Petit-Palais (10) 4–0 Tour Sportive et Merles Blancs 88 (10) 48. Périgueux Foot (10) 4–3 US Artiguaise (11) 49. USA Montbronn (10) 2–0 US Annesse-et-Beaulieu (10) 50. AS Bel-Air (11) 3–1 JS Garat-Sers-Vouzan (11) 51. AS Chazelles (11) 0–0 OFC Ruelle (8) 52. SL Châteaubernard (11) 0–3 SC Cadaujac (8) 53. SJ Artigues (12) 0–3 Alliance Foot 3B (8) 54. SC Mouthiers (9) 7–1 US Nord Gironde (10) 55. US Châteauneuf 16 (10) 0–3 AS Merpins (7) 56. ES Thénacaise (11) 0–3 RC Bordeaux Métropole (8) 57. US La Gémoze (10) 1–1 USJ Saint-Augustin Club Pyrénées Aquitaine (10) 58. ALFC Fontcouverte (10) 3–3 FC Côteaux Bordelais (8) 59. CS Saint-Michel-sur-Charente (9) 1–0 US Saujon (9) 60. FC Casteljaloux (10) 3–0 CA Castets-en-Dorthe (11) 61. ASSA Pays du Dropt (8) 4–0 AS Miramont-Lavergne (9) 62. FC Nérac en Albret (9) 1–2 Entente Boé Bon-Encontre (7) 63. AS Pays de Montaigne et Gurçon (9) 2–2 VS Caudrot (9) 64. Football Sud Bastide (10) 3–1 FC Vallée de la Dordogne (11) 65. AS Côteaux Dordogne (10) 1–7 Confluent Football 47 (7) 66. FC Espagnol Pau (11) 0–3 Labenne OSC (8) 67. FC Lacajunte-Tursan (9) 2–2 FC Gan (10) 68. Bleuets Pau (8) 3–4 FC Saint-Vincent-de-Paul (9) 69. SC Arthez Lacq Audejos (8) 3–0 AS Mourenx-Bourg (9) 70. US Armagnac (11) 2–4 FC Parentis (9) 71. FC La Ribère (8) 2–1 US Garein (9) 72. ES Montoise (8) 1–4 AS Facture-Biganos Boïens (8) 73. Violette Aturine (8) 2–0 AS des Églantines de Hendaye (9) 74. Biscarrosse OFC (8) 0–2 FC Belin-Béliet (8) 75. FC Oloronais (9) 2–0 US Saint-Palais Amikuze (9) 76. Fraternelle Landiras (10) 0–5 FC Saint-Martin-de-Seignanx (8) 77. Patronage Bazadais (8) 1–2 FC Luy de Béarn (8) 78. FC Pays Argentonnais (9) 6–0 Union Cernay-Saint-Genest (10) 79. ES Saint-Amand-sur-Sèvre (11) 3–1 Entente Voulmentin-Saint-Aubin-du-Plain-La Coudre (11) 80. CL Noirlieu-Chambroutet Bressuire (11) 0–3 US Thuré-Besse (10) 81. SC L'Absie-Largeasse/Moutiers-sous-Chantmerle (11) 1–4 ES Aubinrorthais (8) 82. SC Vouzailles (13) 1–2 US Leignes-sur-Fontaine (10) 83. FC Vouneuil-sous-Biard-Béruges (10) 2–1 Amicale Coussay-les-Bois (11) 84. FC ASM (11) 0–3 ES Oyré-Dangé (9) 85. US Cissé (12) 0–10 ES Nouaillé (8) 86. Bel-Air Rocs OC Poitiers (11) 0–3 US Vicq-sur-Gartempe (8) 87. FC Plaine Gâtine (12) 2–3 FC Comores Bressuire (11) 88. US Vergentonnaise (12) 0–7 Inter Bocage FC (9) 89. US Champdeniers-Pamplie (11) 3–2 FC Clazay Bocage (11) 90. Croutelle FC (12) 1–1 US Vouillé (11) 91. ASC Portugais Parthenay et de Gâtine (11) 0–10 FC Jardres (12) 92. FC Chiché (11) 3–2 ACS Mahorais 79 (10) 93. ASA Couronneries (11) 0–0 AS Portugais Châtellerault (8) 94. ES Pays Thénezéen (10) 5–0 US Brion 79 (11) 95. AS Saint-Christophe 86 (12) 0–3 JS Nieuil l'Espoir (8) 96. ES Boismé Clessé (12) 1–1 FC Châtillon (12) 97. AS Sèvres-Anxaumont (10) 0–3 FC Saint-Jean-Missé (11) 98. FC Sud Gâtine (10) 4–0 AAS Saint-Julien-l'Ars (10) 99. AS Poitiers Gibauderie Mahorais (11) 7–1 SA Mauzé-Rigné (11) 100. AS Saint-Léger Montbrillais (11) 1–3 EF Le Tallud (7) 101. AS Saint-Loup Louin (13) 1–4 AS Portugais Cerizay (10) 102. FC Chanteloup-Courlay-Chapelle (10) 4–1 Boivre SC (10) 103. ES Fayenoirterre (11) 1–1 US Mirebeau (11) 104. CEP Poitiers (11) 1–2 Avenir Autize (11) 105. FC Montamisé (10) 3–1 US Saint-Varent Pierregeay (8) 106. Pleumartin-La Roche-Posay FC (12) 0–5 ES Trois Cités Poitiers (9) 107. AS Colombiers (13) 2–2 US Vasléenne (9) 108. ES Saint-Cerbouillé (8) 1–2 FC Fontaine-le-Comte (8) 109. US Avanton (10) 2–1 ES Beaulieu-Breuil (10) 110. FC Pays de l'Ouin (8) 4–1 Ozon FC (9) 111. Biard FC (11) 2–2 Chasseneuil-Saint-Georges FC (9) 112. AS Coulonges-Thouarsais (11) 2–5 FC Airvo Saint-Jouin (9) 113. US Vrère-Saint-Léger-de-Montbrun (10) 0–3 US Saint-Sauveur (7) 114. AS Sainte-Ouenne (13) 1–1 Espérance Terves (8) 115. CA Saint-Aubin-le-Cloud (9) 4–1 US Nord Vienne (10) 116. ES La Pallu (11) 1–2 ES Saint-Benoit (8) 117. ASPTT Bessines (12) 2–5 ES Ardin (9) 118. US Mauzé-sur-le-Mignon (10) 4–0 JS Angoulins (11) 119. US Lezay (10) 3–1 AS Vérines (11) 120. AS Andilly (10) 1–1 ES Brûlain (10) 121. Amicale Saint-Martin (12) 0–0 FC Rouillac (11) 122. FC de la Soie (11) 1–5 AS Pays Mellois (8) 123. Espoir Haut Vals de Saintonge (11) 1–9 Aunis AFC (9) 124. ES Clussais (11) 2–2 FC Canton de Courçon (11) 125. ES Tonnacquoise-Lussantaise (10) 3–3 DR Boucholeurs-Châtelaillon-Yves (10) 126. AR Cherveux (12) 2–0 FC Haut Val de Sèvre (10) 127. AS Sainte-Néomays Romans (12) 0–1 Capaunis ASPTT FC (8) 128. AS Argenteuil Angerien Poursay-Garnaud (10) 0–3 AAAM Laleu-La Pallice (8) 129. ASS Portugais La Rochelle (11) 3–0 ES Saint-Just-Luzac (9) 130. ACS La Rochelle'' (10) || 2–1 || AS Saint-Martin-lès-Melle (11) |- | 131. || Avenir 79 FC (9) || 3–0 || Entente Soubise Port-des-Barques (10) |- | 132. || ES Muron Genouillé (12) || 0–2 || US Aigrefeuille (9) |- | 133. || AS Exoudun (12) || 2–3 || Breuil-Magné FC (11) |- | 134. || US Prahecq (12) || 0–6 || AS Réthaise (7) |- | 135. || Stade Boisseuillais (12) || 2–4 || ESAB 96 FC (10) |- | 136. || ES Mougon (11) || 0–3 || Stade Vouillé (8) |- | 137. || AS Augé/Azay-le-Brûlé (11) || 0–0 || Aviron Boutonnais (9) |- | 138. || US Pexinoise Niort (12) || 1–7 || FC Essouvert Loulay (10) |- | 139. || SEPC Exireuil (11) || 0–4 || FC Boutonnais (10) |- | 140. || AS Blanzay (13) || 0–4 || CS Saint-Angeau (10) |- | 141. || Coqs Rouges Mansle (10) || 1–7 || AS Brie (9) |- | 142. || SC Champagné-Saint-Hilaire (12) || 2–10 || ES Brion-Saint-Secondin (10) |- | 143. || US Lessac (10) || 2–3 || ES Champniers (8) |- | 144. || US Availles-Limouzine (14) || 2–8 || Entente Foot 16 (11) |- | 145. || Taizé-Aizie Les Adjots (12) || 0–4 || Avenir Bellac-Berneuil-Saint-Junien-les-Combes (8) |- | 146. || AS Vars (12) || 1–7 || US Leigné-sur-Usseau (11) |- | 147. || US Abzac (11) || 3–1 || AS Payroux Charroux Mauprévoir (11) |- | 148. || CS Chatain (12) || 0–2 || US Mélusine (9) |- | 149. || FC Vallée du Salleron (13) || 1–3 || Valence-en-Poitou OC (10) |- | 150. || SC Agris (13) || 2–1 || ES Nouic Mézières (12) |- | 151. || AS Saint-Saviol (12) || 1–11 || ACG Foot Sud 86 (10) |- | 152. || AS La Jonchère-Saint-Maurice (11) || 0–12 || SA Le Palais-sur-Vienne (7) |- | 153. || US Saint-Fiel (9) || 1–2 || AS Châteauneuf-Neuvic (8) |- | 154. || Boisseuil FC (10) || 1–0 || US Nantiat (9) |- | 155. || ES Dun-Naillat (10) || 0–2 || Limoges Football (9) |- | 156. || USS Mérinchal (9) || 4–0 || US Vallière (10) |- | 157. || SC Verneuil-sur-Vienne (8) || 3–0 || US Felletin (8) |- | 158. || Diables Bleus Bersac (11) || 2–2 || US Saint-Vaury (9) |- | 159. || FC Saint-Priest-sous-Aixe (10) || 1–1 || US Saint-Léonard-de-Noblat (8) |- | 160. || AS Aiguille Bosmie Charroux (11) || 3–3 || Football Cognacois Cyrien Laurentais (11) |- | 161. || AS Saint-Just-le-Martel (10) || 3–0 || CA Égletons (9) |- | 162. || AC Kurdes Limoges (10) || 2–0 || AS Limoges Roussillon (8) |- | 163. || AS Marcillac Clergoux (11) || 1–1 || AS Saint-Louis Val de l'Aurence (10) |- | 164. || AS Eymoutiers (9) || 0–1 || AS Saint-Junien (8) |- | 165. || USC Bourganeuf (9) || 2–1 || CA Saint-Victurnien (10) |- | 166. || AS Reterre Fontanières (10) || 0–10 || EF Aubussonnais (8) |- | 167. || Vigenal FC Limoges (8) || 3–1 || JS Chambon-sur-Voueize (9) |- | 168. || ES Bénévent-Marsac (9) || 3–1 || RFC Sainte-Feyre (9) |- | 169. || Espoirs La Geneytouse (9) || 3–5 || FC Saint-Brice-sur-Vienne (10) |- | 170. || SC Séreilhac (11) || 1–0 || SC Sardent (9) |- | 171. || CA Peyrat-la-Nonière (9) || 6–1 || US Beaune-les-Mines (9) |- | 172. || ES Evaux-Budelière (10) || 4–6 || US Veyrac (10) |- | 173. || FC Canton d'Oradour-sur-Vayres (10) || 1–2 || US Bessines-Morterolles (8) |- | 174. || AS Saint-Sulpice-le-Guérétois (8) || 1–0 || US Auzances (9) |- | 175. || AS Ambazac (9) || 0–1 || CA Meymac (8) |- | 176. || FC Bassimilhacois (9) || 1–1 || US Pays de Fénelon (10) |- | 177. || AS Saint-Viance (11) || 1–2 || FC Cornilois-Fortunadais (9) |- | 178. || USA Terrasson (11) || 1–5 || Auvézère Mayne FC (9) |- | 179. || Amicale Saint-Hilaire Venersal (10) || 2–2 || FC Thenon-Limeyrat-Fossemagne (7) |- | 180. || FC Spartak Carsac (12) || 0–3 || ES Portugais Brive (10) |- | 181. || ASPO Brive (8) || 5–2 || AS Beynat (8) |- | 182. || FC Saint-Jal (11) || 0–6 || La Thibérienne (8) |- | 183. || Olympique Larche Lafeuillade (9) || 1–1 || SS Sainte-Féréole (8) |- | 184. || Occitane FC (9) || 2–2 || Varetz AC (9) |- | 185. || US La Roche l'Abeille (9) || 2–0 || Entente SR3V (9) |- | 186. || AS Nexon (9) || 4–1 || Condat FC (10) |- | 187. || CA Brignac (11) || 1–1 || Foot Sud 87 (9) |-