Tretinoin/benzoyl peroxide, sold under the brand name Twyneo, is a fixed-dose combination medication used for the treatment of acne. It contains tretinoin, a vitamin A derivative, and benzoyl peroxide, an oxidizing agent.
The U.S. Food and Drug Administration (FDA) approved this medication for use in July 2021. Historically, the co-formulation of these two active ingredients was avoided because benzoyl peroxide typically causes the oxidative degradation of tretinoin when stored together. To address this stability issue, Twyneo employs a silica-based sol-gel microencapsulation technology, which serves as a physical barrier that prevents the benzoyl peroxide from damaging the tretinoin within the vehicle.
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