The 2021 Kentucky Bank Tennis Championships was a professional tennis tournament played on outdoor hard courts. It was the 25th edition of the tournament and was part of the 2021 ATP Challenger Tour. It took place in Lexington, United States, on 26 July–1 August 2021.

Singles main draw entrants Seeds Country Player Rank1 SeedJenson Brooksby1261Alex Bolt1482Maxime Cressy1493Prajnesh Gunneswaran1564Emilio Gómez1685Alejandro Tabilo1726Ernesto Escobedo1827Thanasi Kokkinakis1838 1 Rankings as of 19 July 2021.

Other entrants The following players received a wildcard into the singles main draw: Stefan Dostanic Liam Draxl Govind Nanda

The following players received entry into the singles main draw as alternates: Sasikumar Mukund Shuichi Sekiguchi

The following players received entry from the qualifying draw: Darian King Stefan Kozlov Aidan McHugh Genaro Alberto Olivieri

The following player received entry as a lucky loser: Edan Leshem

Champions Singles

Jason Kubler def. Alejandro Tabilo 7–5, 6–7(2–7), 7–5.

Doubles

Liam Draxl / Stefan Kozlov def. Alex Rybakov / Reese Stalder 6–2, 6–7(5–7), [10–7].

References