The 2021–22 Coupe de France preliminary rounds, Bourgogne-Franche-Comté was the qualifying competition to decide which teams from the leagues of the Bourgogne-Franche-Comté region of France took part in the main competition from the seventh round.

A total of eight teams qualified from the Bourgogne-Franche-Comté preliminary rounds. In 2020–21, UF Mâconnais progressed furthest in the main competition, reaching the round of 64 before losing to FC Saint-Louis Neuweg.

Draws and fixtures

On 8 July 2021, the league declared that 408 teams entered from the region, with 324 entering at the first round stage, 58 exempt to the second round (31 from Régionale 2 and all teams from Régionale 1). 12 Championnat National 3 teams entered at the third round stage, 3 Championnat National 2 teams at the fourth round stage and the remaining 8 clubs being part of the main draw.

The first round draw was published on 9 July 2021. The second round draw was published on 24 August 2021. The third round draw was published on 31 August 2021. The fourth round draw was published on 21 September 2021. The fifth round draw was made on 5 October 2021. The sixth round draw was made on 21 October 2021.

First round These matches were played on 20, 21 and 22 August 2021.

+ First round results: Bourgogne-Franche-Comté Tie no Home team (tier) Score Away team (tier) 1. AS Méziré-Fesches-le-Châtel (8) 4–2 FC Colombe (9) 2. FC Pays de Luxeuil (11) 2–5 SG Héricourt (8) 3. Rougemont Concorde (9) 1–1 FC Pays Minier (10) 4. FC Giro-Lepuix (8) 4–0 Olympique Courcelles-lès-Montbéliard (9) 5. AS Chèvremont (11) 3–4 AS Nord Territoire (9) 6. AS Présentevillers-Sainte-Marie (10) 1–5 UOP Mathay (10) 7. USC Sermamagny (10) 0–7 AS Mélisey-Saint Barthélemy (8) 8. ES Exincourt-Taillecourt (9) 4–2 AS Rougegoutte (10) 9. US Frotey-lès-Vesoul (9) 3–0 FC Forges Audincourt (10) 10. US Pusey (10) 0–8 US Arcey (10) 11. GLS Club 90 (11) 0–1 FC L'Isle-sur-le-Doubs (8) 12. AS Fougerolles (9) 0–1 US Sous-Roches (8) 13. AS Berche-Dampierre-Etouvans (12) 1–8 FC Seloncourt (10) 14. Longevelle SC (9) 2–1 ASC Montbéliard (10) 15. FAC Lougres (11) 2–3 SC Saint Loup-Corbenay-Magnoncourt (8) 16. AS Sainte Suzanne (12) 1–3 ES Trévillers-Thiébouhans (11) 17. ES Réchésy (11) 1–2 AS Guyans-Vennes (9) 18. FC Suarce (12) 2–0 FC Plaimbois-du-Miroir (10 19. US Roches-lès-Blamont (11) 1–2 SR Delle (8) 20. AS Orchamps-Val de Vennes (8) 2–1 US Larians-et-Munans (7) 21. CS Beaucourt (9) 0–3 AS Essert (10) 22. ES Pays Maîchois (8) 2–0 ASFC Belfort (9) 23. AS Feule-Solemont (11) 1–3 AS Courtefontaine-Les Plains (10) 24. ES Charquemont (11) 0–1 AS Frambouhans (11) 25. FC Le Russey (11) 1–1 US Les Fontenelles (10) 26. SCM Valdoie (9) 3–0 AS Pierrefontaine et Laviron (10) 27. US Saint Hippolyte (11) 3–2 US Les Fins (11) 28. AS Danjoutin-Andelnans-Méroux (8) 2–0 AS Hérimoncourt (9) 29. AS Dambelin (12) 2–1 FC Bourogne (12) 30. FC Villars-sous-Écot/Saint-Maurice/Blussans (10) 4–3 RC Voujeaucourt (10) 31. AS Montandon (12) 0–0 ASL Autechaux-Roide (9) 32. US Les Quatre Monts (11) 2–1 ES Les Fonges 91 (9) 33. AS Haut Lison (11) 2–1 ES Doubs (8) 34. ASC Amathay-Longeville (12) 0–8 ES Les Sapins (10) 35. RC Chaux-du-Dombief (10) 4–0 ES Sirod (9) 36. AS Avoudrey (10) 1–1 Amancey-Bolandoz-Chantrans Foot (10) 37. ES Saugette Entre-Roches (9) 4–0 AS Mont d'Usiers (10) 38. ES Dannemarie (9) 2–1 AS Etalans Vernierfontaine (10) 39. Arcade Foot (8) 0–2 CS Frasne (9) 40. FC Massif Haut Doubs (11) 4–0 AS La Rochette (11) 41. AS Fort-du-Plasne (10) 0–2 SC Villers-le-Lac (8) 42. Entente Le Châteleu (10) 0–3 AS Château de Joux (9) 43. US Laveron (11) 3–3 FC Liévremont-Arçon (9) 44. Drugeon Sports (11) 4–0 Étoile Saugette La Chaux de Gilley (10) 45. US Crotenay Combe d'Ain (10) 3–1 FC Haut Jura (8) 46. FC Lac-Remoray-Vaux (10) 3–0 US Foncine (11) 47. AS Genlis (8) 5–0 ALC Longvic (8) 48. FR Archelange-Gredisans-Menotey (11) 0–6 CCS Val d'Amour Mont-sous-Vaudrey (7) 49. CS Auxonnais (8) 2–1 EF Villages (8) 50. US Trois Monts (9) 2–1 ISS Pleure (10) 51. ASDDOM Dijon (11) 2–5 FC Saulon-Corcelles (9) 52. FC Aiserey-Izeure (9) 0–0 AS Saint Usage Saint-Jean-de-Losne (8) 53. FC Remilly (11) 8–1 AS Choisey (11) 54. FC Neuilly-Crimolois Sennecey (10) 6–0 AS Montbarrey (11) 55. FR Rahon (11) 0–5 Jura Stad' FC (8) 56. AS Seurre (12) 0–10 FC Ouges-Fénay (9) 57. AS Foucherans (9) 3–0 FC Plaine 39 (10) 58. ESJA Myon-Chay Intercommunal (11) 1–2 ASC Velotte (10) 59. AS Plateau de La Barêche (11) 4–0 FC Amagney Marchaux (11) 60. US Avanne-Aveney (10) 0–3 FC Grand Besançon (8) 61. FC Chatillon-Devecey (11) 0–4 FC Rochefort Athletic (8) 62. ASC Besançon Mahoraise (10) 1–2 FC Montfaucon-Morre-Gennes-La Vèze (7) 63. FC Brenne-Orain (10) 1–3 PS Dole-Crissey (9) 64. US Prés de Vaux (11) 1–4 FC Val de Loue (9) 65. AS Besançon Espérance (12) 0–3 Jura Nord Foot (10) 66. Thise-Chalezeule FC (10) 3–0 US Grandmont (11) 67. AS Besançon Ouest (12) 2–2 US Doubs Sud (10) 68. FC Aiglepierre (9) 0–3 AS Sâone-Mamirolle (9) 69. AS Beure (10) 3–2 FC Mouchard-Arc-et-Senans (10) 70. FC Émagny Pin (10) 4–1 FC Premier Plateau (9) 71. AS Poussots (11) 1–1 SC Jussey (9) 72. CSL Chenôve (12) 0–3 FC Grésilles (10) 73. Tilles FC (9) 5–1 FC Les 2 Vels (10) 74. US Marey-Cussey (10) 4–2 US Brazey-en-Plaine (11) 75. AS Dijon Toison d'Or (12) 1–8 ES Marnaysienne (9) 76. FC Aignay Baigneux (11) 7–0 FFM La Romaine (11) 77. FC Ahuy (11) 3–0 FC Sennecey-lès-Dijon (12) 78. ASFC Daix (10) 0–3 FC Mirebellois-Pontailler-Lamarche (8) 79. FC Jeunesse Mahoraise (11) 3–4 Espérance Arc-Gray (8) 80. FC Vingeanne (9) 1–1 RC Saônois (9) 81. Val de Norge FC (10) 5–0 Spartak Bressey (10) 82. Dinamo Dijon (11) 0–6 ES Fauverney-Rouvres-Bretenière (7) 83. Auxerre Sports Citoyens (11) 1–4 US Semur-Époisses (9) 84. ASUC Migennes (8) 1–1 AS Gurgy (9) 85. AS Saint-Bris-le-Vineux (9) 1–8 AS Magny (7) 86. ES Héry (9) 2–0 UF Tonnerrois (10) 87. FC Champs-sur-Yonne (9) 2–3 Montbard Venarey (9) 88. AS Chablis (8) 2–1 Monéteau FC (9) 89. AJ Sautourienne (10) 2–0 Entente Châtel-Gérard Nucerien (9) 90. FC Saint Rémy les Montbard (9) 1–2 US Varennes (9) 91. AS Précy (12) 0–18 Union Châtillonniase Colombine (10) 92. SC Vitteaux (11) 0–3 FC Aigles Auxerre (12) 93. AS Varzy (11) 0–6 US Toucycoise (9) 94. US Joigny (10) 0–2 CA Saint-Georges (8) 95. CSP Charmoy (12) 3–0 Cosnois FC (11) 96. FC Coulanges-la-Vineuse (10) 0–3 US Dionysienne (10) 97. FC Cheu 0–3 US Cerisiers (8) 98. ASC Pougues (9) 3–2 FC Gatinais en Bourgogne (10) 99. JS Saint-Révérien (11) 0–5 Jeunesse Sénonaise (10) 100. USC Charny (12) 1–2 AS Montoise (9) 101. AS Pouilly-sur-Loire (11) 0–1 FC Chevannes (9) 102. Saint-Fargeau SF (10) 4–0 SC Gron Véron (10) 103. FC Fleury-la-Vallée (10) 1–2 Amicale Franco-Portugais Sens (9) 104. ES Saint-Germain-du-Plaine-Baudrières (10) 2–1 Entente Sud Revermont (8) 105. FC Saint-Lupicin (12) 2–2 FC Charette (10) 106. Olympique Montmorot (9) 0–8 RC Bresse Sud (8) 107. US Revermontaise (10) 1–4 JS Simard (11) 108. AS Tournus (12) 2–4 FC Petite Montagne (10) 109. FC Courlaoux (12) 0–6 US Coteaux de Seille (8) 110. FC Macornay Val de Sorne (10) 4–4 IS Bresse Nord (10) 111. FC Pont de la Pyle (10) 1–1 AS Condal-Dommartin (11) 112. AS Sornay (8) 4–3 SC Châteaurenaud (9) 113. AS Vaux-lès-Saint-Claude (9) 5–2 AFC Cuiseaux-Champagnat (10) 114. US Lessard-en-Bresse (9) 1–3 IS Saint-Usuge (9) 115. ES Branges (10) 0–0 FC Épervans (10) 116. AS Aromas (11) 1–1 CS Mervans (8) 117. FC Hurigny (11) 1–3 Dun Sornin Chauffailles Brionnais (9) 118. Sancé FC (10) 1–3 SR Clayettois (8) 119. FC La Roche-Vineuse (9) 7–1 JS Mâconnaise (8) 120. JS Crechoise (10) 3–1 FC Clessé 121. FC Sennecé-lès-Mâcon (9) 0–3 US Sennecey-le-Grand et son Canton (8) 122. FC Dompierre-Matour (10) 0–2 Joncy Salornay Val de Guye (10) 123. AS Laizé (11) 0–7 Mâcon FC (8) 124. CS Tramayes (11) 4–5 US Cluny (8) 125. Viré Lugny Haut Mâconnais (11) 0–5 RC Flacé Mâcon (10) 126. ES Pays Charollais (10) 0–4 Digoin FCA (9) 127. Génelard Perrecy FC (9) 0–0 US Bourbon-Lancy FPT (10) 128. US Rigny-sur-Arroux (9) 1–0 JF Palingeois (9) 129. AS Neuvyssois (10) 1–0 AS Saint-Vincent-Bragny (9) 130. AS Charrin (10) 1–3 Sud Foot 71 (8) 131. AS Vendenesse-sur-Arroux (11) 1–3 ES Toulon-sur-Arroux (10) 132. Entente Antully Saint-Émiland Auxy (11) 5–2 AS Ciry-le-Noble (9) 133. UF La Machine (8) 5–0 AS Guerigny Urzy (8) 134. FC Château-Chinon-Arleuf (10) 9–1 USC Franco-Portugais Garchizy (10) 135. US Coulanges-lès-Nevers (9) 1–1 FC Nevers 58 (8) 136. CS Corbigeois (9) 0–1 AS Fourchambault (9) 137. Chaulgnes FC (9) 1–5 Étoile Sud Nivernaise 58 (8) 138. RC Nevers-Challuy Sermoise (8) 0–1 FC Nevers Banlay (9) 139. FREP Luthenay (10) 1–2 FC Sud Loire Allier 09 (9) 140. RC Maupas (12) 0–1 JS Marzy (9) 141. US Saint-Pierre Foot 58 (10) 3–0 US Luzy-Millay (10) 142. CF Talant (12) 0–11 Chalon ACF (8) 143. AS Lacanche (10) 3–0 FC Verdunois (11) 144. JS Chagnotine (12) 0–3 AS Châtenoy-le-Royal (8) 145. SLF Sevrey (11) 1–2 ÉFC Demigny (10) 146. US Buxynoise (9) 3–2 AS Varennes-le-Grand (10) 147. US Meursault (8) 3–0 ASL Lux (9) 148. JS Rully (9) 6–4 FC Autun (10) 149. AS Cheminots Chagnotins (10) 1–3 ASC Plombières-Lès-Dijon (9) 150. ASI Vougeot (11) 0–0 AS Pouilly-en-Auxois (8) 151. FC Corgoloin-Ladoix (8) 3–5 AS Gevrey-Chambertin (9) 152. Flamboyants Football Chalonnais (10) 0–3 Team Montceau Foot (9) 153. US Savigny-Chassagne (10) 3–5 FC Marmagne (10) 154. Montcenis FC (10) 4–1 CS Orion (11) 155. Saint-Vallier Sport (10) 4–2 SC Etangois (10) 156. Sassenay-Virey-Lessard-Fragnes (9) 1–5 FC Sombernon-Gissey (10) 157. US Givry-Saint-Désert (10) 1–1 UFC de l'Ouche (11) 158. AS Canton du Bligny-sur-Ouche (12) 1–5 AS Mellecey-Mercurey (10) 159. FC Saint-Rémy (9) 3–1 FLL Gergy-Verjux (9) 160. EJS Épinacoise (10) 3–3 FC Bois du Verne (11) 161. FR Saint Marcel (7) 8–0 US Nolay (11) 162. US Blanzy (9) 2–2 US Crissotine (9)

Second round These matches were played on 28 and 29 August 2021.