Quiles is a surname. Notable people with the surname include:
Alberto Quiles (born 1995), Spanish footballer Antonio Jiménez Quiles (1934–2023), Spanish cyclist Diamilette Quiles (born 1985), Puerto Rican baseball player Eduardo Quiles (born 1940), Spanish playwright German Quiles (born 1939), American politician José Rodríguez Quiles, Puerto Rican politician Justin Quiles (born 1990), American singer Paul Quilès (1942–2021), French politician Ricky Quiles (born 1970), American boxer Waldemar Quiles (born 1940), Puerto Rican politician
See also Copo Quile, village and rural municipality in Argentina