The 2021–22 Coupe de France preliminary rounds, overseas departments and territories made up the qualifying competition to decide which teams from the French Overseas Departments and Territories took part in the main competition from the seventh round.

A total of eleven clubs qualified from the overseas leagues, two each from Guadeloupe, French Guiana, Martinique, Réunion, and one each from Mayotte, New Caledonia and Tahiti. In 2020–21 Club Franciscain from Martinique survived longest in the competition, beating a number of overseas clubs in playoff rounds to reach the round of 32, equalling the record for an overseas team's progression in the competition. They eventually lost to Ligue 1 club Angers.

Mayotte A total of 80 teams from the four division of the Mayotte league entered the competition. The preliminary round draw was published on 11 June 2021, with 16 ties between clubs from Régional 4, the lowest division, and one team exempt to the first round.

A second preliminary round draw was due to be published in early July, but on 6 July 2021 the league announced that all teams would be qualified directly for the first round. The first round draw, including the remaining clubs, was published on 22 July 2021.

The round of 32 was drawn on 20 August 2021, originally to be played on 4 September 2021. The round of 16 and quarter final draws were published on 15 September 2021. The semi-final draw was published on 1 October 2021.

Preliminary round (Mayotte) These matches were played on 27 June 2021. + preliminary round results: Mayotte Tie no Home team (tier) Score Away team (tier) 1. Espoir Mtsapéré (R4) 3–2 ACSJ M'Liha (R4) 2. FC du Sud (R4) 2–0 CJ Mronabéja (R4) 3. Flamme d'Hajangoua (R4) 3–1 US Mtsangamboua (R4) 4. Trévansi SC Tahity (R4) 1–2 AS Kahani (R4) 5. Maharavo FC (R4) 5–1 US Mtsamoudou (R4) 6. FC Bouyouni (R4) 0–3 USJ Tsararano (R4) 7. Feu du Centre (R4) 2–2 Espoir Club de Longoni (R4) 8. FC Ylang de Koungou (R4) 5–1 Étoile de Hapandzo (R4) 9. ACSJ Alakarabu (R4) 3–1 Voulvavi Sport & Culture (R4) 10. ASCEE Nyambadao (R4) 2–0 AS Ongojou (R4) 11. AS Papillon d'Honneur (R4) 0–3 Tornade Club de Majicavo-Lamir (R4) 12. FMJ Vahibé (R4) 2–1 Lance Missile (R4) 13. FC Passi M'Bouini (R4) 1–3 US d'Acoua (R4) 14. CS M'ramadoudou (R4) 1–4 FC Mtsankandro (R4) 15. US Bandréle (R4) 0–1 FCO Tsingoni (R4) Note: Mayotte League structure (no promotion to French League structure):Régionale 1 (R1)Régionale 2 (R2)Régionale 3 (R3)Régionale 4 (R4)

First round (Mayotte) These matches were played on 7 and 8 August 2021, with one postponed until 18 September 2021. + First round results: Mayotte Tie no Home team (tier) Score Away team (tier) 1. Racine du Nord (R3) 4–3 US Ouangani (R3) 2. VSS Hagnoudrou (R3) 1–2 Enfants de Mayotte (R2) 3. FC Labattoir (R2) 0–1 AS Neige (R2) 4. FCO Tsingoni (R4) 1–3 AOE Chiconi (R3) 5. Foudre 2000 (R2) 2–0 AS Bandraboua (R1) 6. Miracle du Sud (R3) 3–1 AJ Mtsahara (R3) 7. FC Chiconi (R3) 3–2 AS Kahani (R4) 8. Flamme d'Hajangoua (R4) 1–5 AS Defense de Kawéni (R2) 9. FC Kani-Bé (R3) 5–0 Choungui FC (R3) 10. Mahabou SC (R3) 5–1 ASC Wahadi (R3) 11. VCO Vahibé (R3) 2–1 ACSJ Alakarabu (R4) 12. Feu du Centre (R4) 2–2 FMJ Vahibé (R4) 13. FC Ylang de Koungou (R4) 5–3 N'Drema Club (R3) 14. ASCEE Nyambadao (R4) 1–3 US Kavani (R3) 15. USJ Tsararano (R4) 3–1 FC Shingabwé (R4) 16. Espérance d'Iloni (R3) 1–1 ASJ Moinatrindri (R1) 17. RC Barakani (R3) 1–2 Diables Noirs (R1) 18. Maharavo FC (R4) 4–2 FC Mtsankandro (R4) 19. Olympique de Miréréni (R2) 2–1 AJ Kani-Kéli (R2) 20. ASC Abeilles (R2) 3–1 FC Mtsapéré (R1) 21. TCO Mamoudzou (R3) 1–0 USC Labattoir (R3) 22. Etincelles Hamjago (R3) 0–3 AS Jumeaux de M'zouazia (R1) 23. Tornade Club de Majicavo-Lamir (R4) 1–0 USC Kangani (R2) 24. Enfant du Port (R3) 2–3 AS Rosador (R1) 25. Espoir Mtsapéré (R4) 1–2 FC Dembeni (R2) 26. Pamandzi SC (R3) 2–0 USC Anteou Poroani (R1) 27. FC Sohoa (R3) 0–1 AS Sada (R1) 28. ASJ Handréma (R3) 3–2 Tchanga SC (R1) 29. US D'Acoua (R4) 1–1 Bandrélé FC (R2) 30. FC Majicavo (R2) 1–3 USCJ Koungou (R1) 31. RC Tsimkoura (R4) 1–5 ASC Kaweni (R1) 32. FC du Sud (R4) 0–3 UCS Sada (R1) Note: Mayotte League structure (no promotion to French League structure):Régionale 1 (R1)Régionale 2 (R2)Régionale 3 (R3)Régionale 4 (R4)

Round of 32 (Mayotte) These matches were played on 11 and 12 September 2021, with one postponed until 22 September 2021. + Round of 32 results: Mayotte Tie no Home team (tier) Score Away team (tier) 1. FC Kani-Bé (R3) 2–3 Diables Noirs (R1) 2. Feu du Centre (R4) 0–0 Miracle du Sud (R3) 3. FC Chiconi (R3) 2–3 AS Rosador (R1) 4. AS Jumeaux de M'zouazia (R1) 4–0 AS Neige (R2) 5. Mahabou SC (R3) 3–2 Racine du Nord (R3) 6. Enfants de Mayotte (R2) 1–1 AS Sada (R1) 7. Pamandzi SC (R3) 3–1 VCO Vahibé (R3) 8. USCJ Koungou (R1) 1–0 Olympique de Miréréni (R2) 9. AS Defense de Kawéni (R2) 2–1 Espérance d'Iloni (R3) 10. US Kavani (R3) 2–0 ASC Abeilles (R2) 11. Maharavo FC (R4) 0–2 UCS Sada (R1) 12. Tornade Club de Majicavo-Lamir (R4) 1–2 Foudre 2000 (R2) 13. USJ Tsararano (R4) 1–2 Bandrélé FC (R2) 14. ASJ Handréma (R3) 1–0 ASC Kaweni (R1) 15. FC Ylang de Koungou (R4) 0–5 AOE Chiconi (R3) 16. FC Dembeni (R2) 1–0 TCO Mamoudzou (R3) Note: Mayotte League structure (no promotion to French League structure):Régionale 1 (R1)Régionale 2 (R2)Régionale 3 (R3)Régionale 4 (R4)

Round of 16 (Mayotte) These matches were played on 25 September 2021, with one postponed until 2 October 2021. + Round of 16 results: Mayotte Tie no Home team (tier) Score Away team (tier) 1. AS Rosador (R1) 1–0 Diables Noirs (R1) 2. Bandrélé FC (R2) 0–1 AS Jumeaux de M'zouazia (R1) 3. Miracle du Sud (R3) 4–2 Foudre 2000 4. FC Dembeni (R2) 2–0 Mahabou SC (R3) 5. AS Sada (R1) 3–1 USCJ Koungou (R1) 6. US Kavani (R3) 0–1 UCS Sada (R1) 7. ASJ Handréma (R3) 0–0 AS Defense de Kawéni (R2) 8. AOE Chiconi (R3) 2–2 Pamandzi SC (R3) Note: Mayotte League structure (no promotion to French League structure):Régionale 1 (R1)Régionale 2 (R2)Régionale 3 (R3)Régionale 4 (R4)

Quarter final (Mayotte) These matches were played on 2 October 2021, with one postponed until 9 October 2021. + Quarter Final: Mayotte Tie no Home team (tier) Score Away team (tier) 1. Miracle du Sud (R3) 0–4 AS Rosador (R1) 2. Pamandzi SC (R3) 2–3 FC Dembeni (R2) 3. UCS Sada (R1) 2–0 AS Sada (R1) 4. ASJ Handréma (R3) 0–1 AS Jumeaux de M'zouazia (R1) Note: Mayotte League structure (no promotion to French League structure):Régionale 1 (R1)Régionale 2 (R2)Régionale 3 (R3)Régionale 4 (R4)

Semi final (Mayotte) These matches were played on 19 October 2021. + Semi Final: Mayotte Tie no Home team (tier) Score Away team (tier) 1. AS Rosador (R1) 4–1 FC Dembeni (R2) 2. AS Jumeaux de M'zouazia (R1) 2–0 UCS Sada (R1) Note: Mayotte League structure (no promotion to French League structure):Régionale 1 (R1)Régionale 2 (R2)Régionale 3 (R3)Régionale 4 (R4)

Final (Mayotte) This match was played on 30 October 2021. + Final: Mayotte Tie no Home team (tier) Score Away team (tier) 1. AS Rosador (R1) 0–4 AS Jumeaux de M'zouazia (R1) Note: Mayotte League structure (no promotion to French League structure):Régionale 1 (R1)Régionale 2 (R2)Régionale 3 (R3)Régionale 4 (R4)

Réunion As was the case last season, just sixteen teams were entered into the draw, all from Régionale 1, the top division of the Réunion football league. The calendar, comprising three qualifying rounds (named fourth, fifth and sixth) was published in May 2021.

The fourth round draw was made on 13 July 2021.

Fourth round (Réunion) These matches were played on 18 and 28 July 2021, and 7 September 2021.

+Fourth round results: Réunion Tie no Home team (tier) Score Away team (tier) 1. JS Saint-Pierroise (R1) 3–0 Saint Denis EDFA (R1) 2. La Tamponnaise (R1) 0–0 ASC Makes (R1) 3. SS Jeanne d'Arc (R1) 0–0 ACF Piton Saint-Leu (R1) 4. AS Capricorne (R1) 2–0 AF Saint-Louisien (R1) 5. AS Excelsior (R1) 2–0 FC Parfin Saint-André (R1) 6. Saint-Denis FC (R1) 0–0 AS Bretagne (R1) 7. Trois Bassins FC (R1) 3–0 AS Marsouins (R1) 8. US Sainte-Marienne (R1) 1–1 Saint-Pauloise FC (R1) Note: Reúnion League structure (no promotion to French League structure):Régionale 1 (R1)Régionale 2 (R2)

Fifth round (Réunion) These matches were played on 29 September 2021. +Fifth round results: Réunion Tie no Home team (tier) Score Away team (tier) 1. JS Saint-Pierroise (R1) 3–0 AS Capricorne (R1) 2. ASC Makes (R1) 1–0 SS Jeanne d'Arc (R1) 3. Trois Bassins FC (R1) 1–1 AS Excelsior (R1) 4. Saint-Denis FC (R1) 2–1 Saint-Pauloise FC (R1) Note: Reúnion League structure (no promotion to French League structure):Régionale 1 (R1)Régionale 2 (R2)

Sixth round (Réunion) These matches were played on 23 and 24 October 2021. +Sixth round results: Réunion Tie no Home team (tier) Score Away team (tier) 1. JS Saint-Pierroise (R1) 0–1 ASC Makes (R1) 2. AS Excelsior (R1) 2–3 Saint-Denis FC (R1) Note: Reúnion League structure (no promotion to French League structure):Régionale 1 (R1)Régionale 2 (R2)

French Guiana A total of 33 teams from the two divisions of the French Guiana league entered the competition. This required a single-fixture round to take place before the first full round. The round naming convention used by the league aligns with those used for the mainland competition, so this competition starts with the second round. The draw for both second and third rounds was published on 9 October 2021.

Second round (French Guiana) This match was played on 16 October 2021. + Second round results: French Guiana Tie no Home team (tier) Score Away team (tier) 1. ASC Karib (R1) 1–1 SC Kouroucien (R1) Note: French Guiana League structure (no promotion to French League structure):Régional 1 (R1)Régional 2 (R2)

Third round (French Guiana) These matches were played on 16 and 23 October 2021. + Third round results: French Guiana Tie no Home team (tier) Score Away team (tier) 1. US Sinnamary (R1) 3–0 US Macouria (R2) 2. AJ Balata Abriba (R2) 1–4 ASC Kawina (none) 3. ASC Rémire (R1) 5–3 USC Montsinéry-Tonnegrande (R1) 4. RC Maroni (*) 4–4 FC Family (none) 5. ASL Sport Guyanais (R2) 3–0 Kourou FC (R2) 6. EF Iracoubo (R1) 2–2 ASC Armire (R2) 7. FC Oyapock (R1) 1–2 ASC Agouado (R1) 8. USL Montjoly (R2) 4–4 USC De Roura (R2) 9. ASCS Maripasoula (none) 3–0 Cosma Foot (R2) 10. AJ Saint-Georges (R1) 0–5 US de Matoury (R1) 11. ASE Matoury (R1) 1–1 ASC Karib (R1) 12. Loyola OC (R1) 2–1 Olympique Cayenne (R1) 13. ASU Grand Santi (R1) 3–0 US Saint-Élie (R2) 14. CSC Cayenne (R1) 1–0 Le Geldar De Kourou (R1) 15. ASC Ouest (R1) 3–0 Dynamo De Soula (R2) 16. ASC Arc-en-Ciel (R2) 0–3 Yana Sport Elite Academy (R2) Note: French Guiana League structure (no promotion to French League structure):Régional 1 (R1)Régional 2 (R2)

Fourth round (French Guiana) These matches were played on 23 and 30 October 2021. + Fourth round results: French Guiana Tie no Home team (tier) Score Away team (tier) 1. ASC Agouado (R1) 3–1 FC Family (none) 2. USL Montjoly (R2) 0–4 US Sinnamary (R1) 3. ASC Kawina (none) 7–2 ASCS Maripasoula (none) 4. US de Matoury (R1) 1–1 ASU Grand Santi (R1) 5. ASE Matoury (R1) 4–1 Loyola OC (R1) 6. ASC Armire (R2) 1–1 CSC Cayenne (R1) 7. ASL Sport Guyanais (R2) 1–6 ASC Rémire (R1) 8. Yana Sport Elite Academy (R2) 1–7 ASC Ouest (R1) Note: French Guiana League structure (no promotion to French League structure):Régional 1 (R1)Régional 2 (R2)

Fifth round (French Guiana) These matches were played on 3 November 2021. + Fifth round results: French Guiana Tie no Home team (tier) Score Away team (tier) 1. ASC Ouest (R1) 0–0 ASC Kawina (none) 2. ASC Rémire (R1) 2–1 ASC Agouado (R1) 3. CSC Cayenne (R1) 3–1 US Sinnamary (R1) 4. ASU Grand Santi (R1) 3–1 ASE Matoury (R1) Note: French Guiana League structure (no promotion to French League structure):Régional 1 (R1)Régional 2 (R2)

Sixth round (French Guiana)

These matches were played on 6 November 2021.