Ostos is a Spanish surname. Notable people with the surname include:
César Augusto Verástegui Ostos (born 1966), Mexican politician Luis Gerardo Ostos (born 1962), Mexican entrepreneur, Mexico and U.S. Javier Ostos Mora (1916-2008), Mexican lawyer Julio Ostos (born 1953), Venezuelan chess master Raymond Munoz Ostos (born 1963), American, Spanish-Mexican U.S. Army Military Officer Luis Ostos (born 1992), Peruvian long-distance runner