Pullicino is a Maltese and Italian surname. Notable people with the surname include:
Alberto Pullicino (1719–1759), Maltese painter George Pullicino (born 1964), Maltese politician Giorgio Pullicino (1779–1851), Maltese painter, architect, and professor of drawing and architecture Jeffrey Pullicino Orlando (born 1963), Maltese politician Joseph Said Pullicino, Chief Justice of Malta Peter Pullicino (born 1976), Australian footballer