Choptank may refer to a location in the eastern United States or a former Native American tribe:
Choptank people
Communities Choptank, Maryland, Caroline County Choptank Mills, Delaware, Kent County
Other Choptank (Middletown, Delaware), listed on the National Register of Historic Places listings in southern New Castle County, Delaware Choptank Electric Cooperative, a not-for-profit energy organization Choptank River, a tributary of Chesapeake Bay Choptank River Fishing Pier, on the Choptank River Choptank River Light, a lighthouse near Oxford, Maryland