José A. Santos (born 1961) is a retired Chilean thoroughbred jockey.
Jose Santos or José Santos may also refer to:
José Santos Becerra José Santos Chocano (1875–1934) José Santos González Vera (1897–1970), a Chilean anarchist writer José Santos Guardiola (1816–1862) José Santos Quinteros (1865–1951), a Bolivian lawyer, professor and politician José Santos Poyatos (born 1962), an athlete from Spain José Santos Ramírez (c. 1790–1851), an Argentine soldier Jose Santos Rios (1939–2018), a Northern Mariana Islands politician José Santos Romero (born 1951), an Argentine football manager and former player José Santos Salas (1888–1955), a Chilean physician and politician José Santos Valdés (born 1997), a Mexican sport shooter José Santos Zelaya (1853–1919), President of Nicaragua José Santos, a pseudonym of the American composer Lee Orean Smith