Nurse is an Old French surname, originally denoting the occupation of a name bearer, but eventually becoming hereditary. Early uses were recorded in England in the 14th century and later. Today, the surname is most common in the United States, the United Kingdom, Canada, and the Caribbean. Smaller populations exist in Australia, New Zealand, and South Africa.

Notable people with the surname include: Ashley Nurse (born 1988), Barbadian cricketer

Chris Nurse (born 1984), Guyanese footballer Cristy Nurse (born 1986), Canadian rower Dan Nurse (1874–1959), English footballer

George Nurse (VC) (1873–1945), Irish recipient of the Victoria Cross Jon Nurse (born 1981), Barbadian football coach and former player Jonathan Nurse (cricketer) (born 1885), Guyanese cricketer

Negus Nurse (born 1982), Guyanese singer

Phil Nurse (born 1963), English Muay Thai coach

Roy Nurse (1919–1991), New Zealand international rugby league footballer

Ryan Nurse (born 1983), Barbadian cricketer Sandy Nurse (born 1984), American politician

Tim Nurse (born 1999), English field hockey player

William Nurse (1832–1885), Member of the New Zealand Legislative Council

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